Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study
| Autor: | Ian T Meredith, H.M. Omar Farouque, James D. Cameron, Sarah Anne Hope, Mauro Baldi, M. Leung, Clyde B. Schechter |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Brachial Artery Flavonols Ischemia Placebo-controlled study Hemodynamics Coronary Artery Disease Beverages Coronary artery disease Double-Blind Method Forearm Internal medicine medicine.artery medicine Humans Brachial artery Aged Cacao business.industry Microcirculation General Medicine Middle Aged medicine.disease Surgery Vasodilation medicine.anatomical_structure Regional Blood Flow Vascular resistance Cardiology Female Vascular Resistance Endothelium Vascular business Cell Adhesion Molecules Biomarkers Blood vessel |
| Zdroj: | Clinical Science. 111:71-80 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs20060048 |
| Popis: | Evidence suggests that flavonoid-containing diets reduce cardiovascular risk, but the mechanisms responsible are unclear. In the present study, we sought to determine the effect of flavanol-rich cocoa on vascular function in individuals with CAD (coronary artery disease). Forty subjects (61±8 years; 30 male) with CAD were recruited to a 6-week randomized double-blind placebo-controlled study. Subjects consumed either a flavanol-rich chocolate bar and cocoa beverage daily (total flavanols, 444 mg/day) or matching isocaloric placebos daily (total flavanols, 19.6 mg/day) for 6 weeks. Brachial artery FMD (flow-mediated dilation) and SAC (systemic arterial compliance) were assessed at baseline, 90 min following the first beverage and after 3 and 6 weeks of daily consumption. Soluble cellular adhesion molecules and FBF (forearm blood flow) responses to ACh (acetylcholine chloride; 3–30 μg/min) and SNP (sodium nitroprusside; 0.3–3 μg/min) infusions, forearm ischaemia and isotonic forearm exercise were assessed at baseline and after 6 weeks. FMD, SAC and FBF responses did not differ between groups at baseline. No acute or chronic changes in FMD or SAC were seen in either group. No difference in soluble cellular adhesion molecules, FBF responses to ischaemia, exercise, SNP or ACh was seen in the group receiving flavanol-rich cocoa between baseline and 6 weeks. These data suggest that over a 6-week period, flavanolrich cocoa does not modify vascular function in patients with established CAD. |
| Databáze: | OpenAIRE |
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