Skeletal muscle changes in chronic alcoholic patients. A conventional, histochemical, ultrastructural and morphometric study
| Autor: | J. M. Rivera‐Pomar, A. del Villar Negro, J. Merino Angulo |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Neuromuscular disease Biopsy Biology chemistry.chemical_compound Liver disease Myofibrils Liver Cirrhosis Alcoholic medicine Humans Myopathy Adenosine Triphosphatases Glycogen medicine.diagnostic_test Myositis Muscles Skeletal muscle Histology General Medicine Middle Aged medicine.disease Lipid Metabolism Mitochondria Muscle Alcoholism medicine.anatomical_structure Neurology chemistry Female Neurology (clinical) medicine.symptom Myofibril |
| Zdroj: | Acta neurologica Scandinavica. 70(3) |
| ISSN: | 0001-6314 |
| Popis: | Muscle biopsies of 20 alcoholic patients (15 males and 5 females), most of whom had liver disease and with no clinical or analytical evidence of neuromyopathy, were studied. 10 abstemious patients with no neuromuscular disease were selected as controls. Conventional histology failed to show significant skeletal muscle changes. A characteristic histochemical picture of tubular aggregates was found in one patient. An enlargement of the intermyofibrillar space with increase in glycogen deposition and fat droplets were detected ultrastructurally while 2 of the patients showed tubular aggregates. The mitochondriae of the alcoholic patients had a smaller perimeter and area than those of the control group (P less than 0.004 and P less than 0.008, respectively). These results suggest that the prolonged ingestion of alcohol can cause a mitochondrial alteration only evidenced by morphometry, with poor clinical, biochemical, electrophysiological and histological expression of myopathy. These findings can represent an early stage of alcoholic skeletal muscle injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|