Comparison of the efficacy of cryotherapy and compression therapy for preventing nanoparticle albumin-bound paclitaxel-induced peripheral neuropathy: A prospective self-controlled trial

Autor: Isao Yokota, Norito Katoh, Ryo Takagi, Yoshimi Ouchi, Minako Hiramatsu, Yuko Kanbayashi, Yusuke Tabuchi, Koichi Sakaguchi, Takeshi Ishikawa, Tetsuya Taguchi, Katsuhiko Nakatsukasa, Fuminao Kanehisa
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Surgical glove
Adult
medicine.medical_specialty
Paclitaxel
medicine.medical_treatment
Urology
Cryotherapy
Breast Neoplasms
Nab-paclitaxel
lcsh:RC254-282
law.invention
03 medical and health sciences
0302 clinical medicine
Breast cancer
Randomized controlled trial
law
Albumins
Compression Bandages
medicine
Compression therapy
Humans
030212 general & internal medicine
Prospective Studies
Aged
Chemotherapy-induced peripheral neuropathy
Aged
80 and over
Chemotherapy
business.industry
Incidence (epidemiology)
Cancer
Peripheral Nervous System Diseases
Common Terminology Criteria for Adverse Events
General Medicine
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Frozen glove
Antineoplastic Agents
Phytogenic
Combined Modality Therapy
Peripheral neuropathy
Treatment Outcome
030220 oncology & carcinogenesis
Surgery
Original Article
Female
business
Zdroj: The Breast : official journal of the European Society of Mastology
Breast, Vol 49, Iss, Pp 219-224 (2020)
ISSN: 1532-3080
0960-9776
Popis: Background Recently, the efficacy of cryotherapy and compression therapy to prevent taxane-induced peripheral neuropathy has been reported. We prospectively compared the efficacy of cryotherapy using a frozen glove (FG) and compression therapy using a surgical glove (SG) to prevent nanoparticle albumin-bound paclitaxel (nab-PTX)-induced peripheral neuropathy. Patients and methods Breast cancer patients who received 260 mg/m2 of nab-PTX were eligible to participate in this trial. Patients wore a FG on one hand (60 min) without changing and two SGs of the same size (i.e., one size smaller than the size that best fit their hand) on the other hand (90 min) during chemotherapy. Peripheral neuropathy was evaluated at each treatment cycle using Common Terminology Criteria for Adverse Events (CTCAE) version 4.0, the Patient Neurotoxicity Questionnaire (PNQ), and the Functional Assessment of Cancer Therapy-Taxane subscale. Temperatures at each fingertip in both groups were measured thermographically. Results Between August 2017 and March 2019, 43 patients were enrolled and 38 were evaluated. No cases showed discordance of peripheral neuropathy between each gloved group in cases of CTCAE ≥ grade 2. In cases of PNQ ≥ grade D, using the Nam equivalence test, the upper test (P = 0.0329) and lower test (P = 0.0052) both showed negative results in comparisons between each gloved group. Fingertip temperature was significantly lower in the FG group than in the SG group after treatment (P
Highlights • Phase II, self-controlled clinical trial, in breast cancer patients. • Prospectively compared the efficacy of cryotherapy and compression therapy for CIPN. • Evaluated efficacy and safety of surgical glove (SG) and frozen glove (FG) for CIPN. • In both FG and SG groups, frequencies of Grade 2 or higher CIPN was 18.4%. • Cryotherapy and compression therapy show comparable efficacy in preventing CIPN.
Databáze: OpenAIRE
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