β1-Adrenoreceptor Polymorphisms and Blood Pressure: 49S Variant Increases Plasma Renin But Not Blood Pressure in Hypertensive Patients
| Autor: | Alastair J Sandilands, Kevin M O’Shaughnessy, null Yasmin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
haplotypes
medicine.medical_specialty hypertension Genotype Hemodynamics Single-nucleotide polymorphism adrenergic receptor 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Plasma renin activity 03 medical and health sciences 0302 clinical medicine Internal medicine Hyperaldosteronism Renin single-nucleotide polymorphisms Renin–angiotensin system Internal Medicine medicine Humans 030212 general & internal medicine Alleles Kidney business.industry blood pressure DNA medicine.disease Blood pressure medicine.anatomical_structure Endocrinology Gene polymorphism Receptors Adrenergic beta-1 Brief Communications business Biomarkers |
| Zdroj: | American Journal of Hypertension |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/hpz019 |
| Popis: | BACKGROUND Activation of beta-1 adrenoreceptor (β1-AR) in the kidney releases renin that plays a major role in the maintenance of blood pressure. Genetic variation in β1-AR could therefore alter the physiological and clinical effects of this hormone. We tested this hypothesis in patients from a primary care cohort being screened for primary hyperaldosteronism (n = 467). METHODS Demographic and hemodynamic data were measured and plasma renin was determined by a standard immunoassay. Subjects were genotyped for the 2 common single-nucleotide polymorphisms Arg389Gly (rs1801253) and Ser49Gly (rs1801252), and thus the 4 possible haplotypes in β1-AR gene. RESULTS In patients being screened for hyperaldosteronism, plasma renin was significantly elevated in Ser49 homozygotes (49SS) compared with Gly49 (49G) allele carriers (0.307 ± 0.03 vs. 0.164 ± 0.05; P = 0.01). However, this did not translate into differences in either blood pressure or heart rate. On the other hand, the Arg389Gly polymorphism did not affect either plasma renin or blood pressure in this group. There was also no evidence that the 2 loci were linked in this group of patients. CONCLUSION These data suggest that in this cohort the Ser49 variant of the Ser49Gly β1-AR gene polymorphism associates with higher renin levels. However, these common β1-AR gene polymorphisms do not affect blood pressure in the same cohort. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|