Assessment of monoamine neurotransmitters in the cortex and cerebellum of gamma-irradiated mice: A neuromodulatory role of Cynodon dactylon
Autor: | Ganesh Sanjeev, N A Vinodini, Nayanatara Arun Kumar, Reshma Kumarchandra, Roopesh Poojary, K Bhagyalakshmi, D. Shivananda Pai |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Cynodon dactylon Cancer Research Cerebellum Health Toxicology and Mutagenesis Pharmacology lcsh:RC254-282 neurotransmitters 03 medical and health sciences Norepinephrine 0302 clinical medicine Oral administration Dopamine Cortex (anatomy) medicine oxidative stress Chemistry gamma radiation lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens cortex 030104 developmental biology medicine.anatomical_structure Monoamine neurotransmitter Epinephrine Oncology 030220 oncology & carcinogenesis Original Article Serotonin medicine.drug |
Zdroj: | Journal of Carcinogenesis Journal of Carcinogenesis, Vol 19, Iss 1, Pp 6-6 (2020) |
ISSN: | 1477-3163 |
Popis: | INTRODUCTION: Radiation is an important tool in the diagnostic and curative treatment of many cancers. Ionizing radiation induces many biochemical changes in the cells. The present study was designed to estimate the level of neurotransmitters in the distinct brain tissue of Swiss albino mice before exposing gamma radiation. MATERIALS AND METHODS: The mice were treated with 0.25 and 1 g/kg body weight of Cynodon dactylon extract (CDE) via oral gavage for 7 days and subjected to 5 Gy of gamma radiation. The estimation of monoamines was performed in the cortex and cerebellum separately. RESULTS: Mice exposed to a sublethal dose 5 Gy of gamma radiation causes a significant decrease in dopamine, norepinephrine, epinephrine, and serotonin levels compared to normal. The mice treated with 0.25 and 1 g/kg body weight of CDE via oral gavage for 7 days showed significant improvement in the level of monoamine neurotransmitters in both the cortex and cerebellum homogenate. CONCLUSION: Oral administration of antioxidant-rich C. dactylon has shown a neuromodulatory effect against radiation-induced depletion of neurotransmitters in the brain tissues. |
Databáze: | OpenAIRE |
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