Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population
| Autor: | João Regis Ivar Carneiro, Bruna Marchesini, Pedro Hernan Cabello, Danielle Dutra Voigt, Giselda M. K. Cabello, Vivianne Galante Ramos, Verônica Marques Zembrzuski, José Firmino Nogueira Neto, Ana Carolina Proença da Fonseca |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine haplotype medicine.medical_specialty QH426-470 Biology 01 natural sciences FTO gene BMI 03 medical and health sciences chemistry.chemical_compound Internal medicine Genetics medicine extreme obesity Molecular Biology Genotyping Triglyceride Haplotype nutritional and metabolic diseases Anthropometry medicine.disease Obesity 030104 developmental biology Endocrinology chemistry Human and Medical Genetics Etiology FTO polymorphisms Body mass index 010606 plant biology & botany |
| Zdroj: | Genetics and Molecular Biology v.43 n.1 2020 Genetics and Molecular Biology Sociedade Brasileira de Genética (SBG) instacron:SBG Genetics and Molecular Biology, Volume: 43, Issue: 1, Article number: e20180264, Published: 06 MAR 2020 Genetics and Molecular Biology, Vol 43, Iss 1 (2020) |
| ISSN: | 1678-4685 1415-4757 |
| Popis: | Obesity is a major public health problem worldwide. It has a complex etiology, influenced by environmental and genetic factors. FTO has been recognized as an important genetic factor for obesity development. This study evaluated the contribution of FTO polymorphisms (rs9939609 and rs17817449) for extreme obesity in terms of the period of obesity onset, anthropometric, and biochemical parameters. The haplotype and the combined effects of FTO risk alleles on obesity susceptibility were evaluated. We investigated 169 normal-weight subjects (body mass index, BMI: 22.8 [21.0; 24.0] kg/m2) and 123 extremely obese individuals (BMI: 47.6 [44.1; 53.1] kg/m2). Genotyping was performed by real time PCR. Our results showed a strong association between FTO variants and extreme obesity. Carriers of the AT haplotype had an increased risk for extreme obesity. Gene scores suggested that the risk of developing extreme obesity was increased 1.37-fold per risk allele added. Both polymorphisms also influenced BMI and body weight. Additionally, rs17817449 influenced triglyceride levels. No effect of FTO variants on the period of obesity onset was found. In conclusion, the FTO polymorphisms showed a strong association with development of extreme phenotype of obesity and adiposity modulation in a Brazilian population. |
| Databáze: | OpenAIRE |
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