Prognostic significance of the combined score of endothelial expression of nucleolin and CD31 in surgically resected non-small cell lung cancer
| Autor: | Liping Zhao, Yang Chen, Zhi Huang Hu, Yan Huang, Cong Xue, Xue Hou, Ying Guo, Yujie Huang, Hongyun Zhao, Li Zhang, Yongzhang Luo |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Oncology CD31 Pathology Lung Neoplasms Microarrays Angiogenesis lcsh:Medicine Lung and Intrathoracic Tumors Metastasis Surgical oncology Carcinoma Non-Small-Cell Lung Basic Cancer Research lcsh:Science Multidisciplinary Tissue microarray RNA-Binding Proteins Middle Aged Prognosis Platelet Endothelial Cell Adhesion Molecule-1 Medicine Female Research Article Adult medicine.medical_specialty Bone Neoplasms Biology Diagnostic Medicine Internal medicine Biomarkers Tumor medicine Humans Clinical significance Lung cancer Aged Neoplasm Staging Proportional Hazards Models lcsh:R Computational Biology Cancers and Neoplasms Endothelial Cells Phosphoproteins medicine.disease Non-Small Cell Lung Cancer lcsh:Q Nucleolin Biomarkers General Pathology |
| Zdroj: | PLoS ONE, Vol 8, Iss 1, p e54674 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Nucleolin is implicated to play a role in angiogenesis, a vital process in tumor growth and metastasis. However, the presence and clinical relevance of nucleolin in human non small cell lung cancer (NSCLC) remains largely unknown. In this study, we explored the expression and prognostic implication of nucleolin in surgically resected NSCLC patients. A cohort of 146 NSCLC patients who underwent surgical resection was selected for tissue microarray. In this tissue microarray, nucleolin expression was measured by immunofluorescence. Staining for CD31, a marker of endothelial cells, was performed to mark blood vessels. A Cox proportional hazards model was used to assess the prognostic significance of nucleolin. Nucleolin expression was observed in 34.2% of all patients, and 64.1% in high CD31 expression patients. The disease-free survival (DFS) was significantly shorter in patients with high nucleolin (CD31(hi)NCL(hi)) compared to patients with low tumor blood vessels (CD31(lo)NCL(lo)) (5 ys of DFS 24% vs 64%, p = 0.002). Such a difference was demonstrated in the following stratified analyses: stage I (p |
| Databáze: | OpenAIRE |
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