Remote-controlled and pulse pressure-guided fluid treatment for adult patients with viral hemorrhagic fevers
| Autor: | Arjen M. Dondorp, Alex P. Salam, Nicholas P. J. Day, Marcus J. Schultz, Jacqueline Deen, Neill K. J. Adhikari, Nicholas J. White, Alexander S. Kekulé, Bridget Wills, Lorenz von Seidlein, Chaisith Sivakorn, Ben S. Cooper, Peter Horby, Piero Olliaro, Alex Kumar |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Resuscitation Hemorrhagic Fevers Viral Hemodynamics Blood Pressure medicine.disease_cause Disease Outbreaks Perspective Piece Capillary leak Lassa Fever Virology Case fatality rate medicine Animals Humans Marburg Virus Disease Intensive care medicine Lassa fever Ebola virus business.industry Hemorrhagic Fever Ebola medicine.disease Hemorrhagic Fevers Infectious Diseases Shock (circulatory) Remote Sensing Technology Fluid Therapy Parasitology medicine.symptom business Algorithms |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene |
| Popis: | Circulatory shock, caused by severe intravascular volume depletion resulting from gastrointestinal losses and profound capillary leak, is a common clinical feature of viral hemorrhagic fevers, including Ebola virus disease, Marburg hemorrhagic fever, and Lassa fever. These conditions are associated with high case fatality rates, and they carry a significant risk of infection for treating personnel. Optimized fluid therapy is the cornerstone of management of these diseases, but there are few data on the extent of fluid losses and the severity of the capillary leak in patients with VHFs, and no specific guidelines for fluid resuscitation and hemodynamic monitoring exist. We propose an innovative approach for monitoring VHF patients, in particular suited for low-resource settings, facilitating optimizing fluid therapy through remote-controlled and pulse pressure–guided fluid resuscitation. This strategy would increase the capacity for adequate supportive care, while decreasing the risk for virus transmission to health personnel. |
| Databáze: | OpenAIRE |
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