The diagnostic value of serum Borrelia burgdorferi antibodies and seroconversion after Lyme neuroborreliosis, a nationwide observational study
| Autor: | Malte M. Tetens, Ram Dessau, Svend Ellermann-Eriksen, Nanna S. Andersen, Charlotte Sværke Jørgensen, Christian Østergaard, Jacob Bodilsen, David F. Damgaard, Jette Bangsborg, Alex Christian Nielsen, Jens Kjølseth Møller, Lars Haukali Omland, Niels Obel, Anne-Mette Lebech |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Serum serology Lyme neuroborreliosis Predictive value General Medicine Borrelia burgdorferi intrathecal antibody index test Antibodies Bacterial Serum antibody test Infectious Diseases Borrelia burgdorferi Group Immunoglobulin M Seroconversion Borrelia burgdorferi Immunoglobulin G Humans Lyme Neuroborreliosis Child Diagnostics |
| Zdroj: | Tetens, M M, Dessau, R, Ellermann-Eriksen, S, Andersen, N S, Jørgensen, C S, Østergaard, C, Bodilsen, J, Damgaard, D F, Bangsborg, J, Nielsen, A C, Møller, J K, Omland, L H, Obel, N & Lebech, A M 2022, ' The diagnostic value of serum Borrelia burgdorferi antibodies and seroconversion after Lyme neuroborreliosis, a nationwide observational study ', Clinical Microbiology and Infection, vol. 28, no. 11, pp. 1500.e1-1500.e6 . https://doi.org/10.1016/j.cmi.2022.06.001 Tetens, M M, Dessau, R, Ellermann-Eriksen, S, Andersen, N S, Jørgensen, C S, Østergaard, C, Bodilsen, J, Damgaard, D F, Bangsborg, J, Nielsen, A C, Møller, J K, Omland, L H, Obel, N & Lebech, A-M 2022, ' The diagnostic value of serum Borrelia burgdorferi antibodies and seroconversion after Lyme neuroborreliosis, a nationwide observational study ', Clinical Microbiology and Infection, vol. 28, no. 11, pp. 1500.e1-1500.e6 . https://doi.org/10.1016/j.cmi.2022.06.001 |
| Popis: | Objectives: Clinical guidelines disagree on the diagnostic usefulness of Borrelia burgdorferi (Bb) serum antibodies (serum-Bb) in investigation of Lyme neuroborreliosis (LNB). We investigated the association between serum-Bb and Bb intrathecal antibody index (Bb-AI) and rates of seroconversion and seroreversion after LNB. Methods: Danish residents who had a Bb-AI and corresponding serum-Bb measured between 1994 and 2020 were identified at all Danish departments of clinical microbiology. We used descriptive statistics to examine the proportions of positive Bb-AI combined with positive or negative serum-Bb antibody tests. Next, the rate of seroconversion and seroreversion among those with positive Bb-AI and either an initial negative or positive serum-Bb was estimated. Results: We included 34 609 individuals with a Bb-AI and corresponding serum-Bb. The proportion of individuals with positive Bb-AI who had negative serum-Bb was 16.8% (95% CI, 15.1–18.6). The proportion of individuals with positive serum-Bb IgM, serum-Bb IgG, or serum-Bb IgM and IgG antibodies who had positive Bb-AI was 10.6% (95% CI, 9.5–11.8), 24.7% (95% CI, 23.0–26.4), and 45.0% (95% CI, 42.4–48.0), respectively. The proportion of children ( |
| Databáze: | OpenAIRE |
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