Neurobehavioral Effects of Cyclohexane in Rat and Human
| Autor: | D.E. Owen, H.H. Emmen, Hans Muijser, B.M. Kulig, J.H.C.M. Lammers, E.M.G. Hoogendijk, Richard H. McKee |
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| Přispěvatelé: | TNO Kwaliteit van Leven |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Test battery Cyclohexane Health Status Central nervous system Motor Activity Neuropsychological Tests Toxicology Models Biological Vocabulary Solvent neurotoxicity Executive Function Young Adult chemistry.chemical_compound Discrimination Psychological Species Specificity Cyclohexanes medicine Animals Humans Behavioral assessments Pharmacokinetics Motor activity Rats Wistar Biology Psychomotor learning Behavior Animal Body Weight Brain Rats medicine.anatomical_structure chemistry Toxicology and Applied Pharmacology Central nervous system effects Anesthesia Visual discrimination Solvents Neurotoxicity Syndromes Psychomotor Performance |
| Zdroj: | International Journal of Toxicology, 6, 28, 488-497 |
| ISSN: | 1092-874X 1091-5818 |
| Popis: | The neurobehavioral effects of inhaled cyclohexane in rats and humans are investigated to define relationships between internal doses and acute central nervous system effects. Rats are exposed for 3 consecutive days at target concentrations of 0, 1.4, 8, and 28 g/m3, 8 h/d. Measurements include standardized observational measures, spontaneous motor activity assessments, and learned visual discrimination performance. Cyclohexane concentrations in blood and brain are measured to assess internal exposure. Human volunteers are exposed for 4 hours to 86 or 860 mg/m3 in 2 test sessions. Neurobehavioral effects are measured using a computerized neurobehavioral test battery. In rats, there are slight reductions in psychomotor speed in the high-exposure group but minimal central nervous system effects. In humans, there are no significant treatment-related effects at the levels tested. |
| Databáze: | OpenAIRE |
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