Echocardiographic Findings in Canine Model of Chagas Disease Immunized with DNA Trypanosoma cruzi Genes
| Autor: | Jesús Vargas-Barrón, María de Lourdes Medina-García, Olivia Rodríguez-Morales, Enrique Parra-Benítez, Emilia Vergara-Bello, Minerva Arce-Fonseca, Francisco-Javier Roldán |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Chagas disease
Cardiac function curve DNA vaccine medicine.medical_specialty Diastole Trypanosoma cruzi Sudden death canine model Internal medicine lcsh:Zoology medicine echocardiography lcsh:QL1-991 Ejection fraction lcsh:Veterinary medicine General Veterinary biology medicine.diagnostic_test business.industry medicine.disease biology.organism_classification Cardiology lcsh:SF600-1100 Animal Science and Zoology Histopathology business Electrocardiography |
| Zdroj: | Animals, Vol 10, Iss 648, p 648 (2020) Animals Volume 10 Issue 4 |
| ISSN: | 2076-2615 |
| Popis: | Chagas disease (ChD) is considered an emerging disease in the USA and Europe. Trypanosoma cruzi genes encoding a trans-sialidase protein and an amastigote-specific glycoprotein were tested as vaccines in canine model. The aim for this study was determining the prophylactic effect of these genes in experimentally infected dogs by echocardiography evaluation to compare with our findings obtained by other techniques published previously. Low fractional-shortening values of non-vaccinated dogs suggested an impairment in general cardiac function. Low left ventricular ejection fraction values found in infected dogs suggested myocardial injury regardless of whether they were vaccinated. Low left ventricular diastolic/systolic diameters suggested that progressive heart damage or heart dilation could be prevented by DNA vaccination. Systolic peak time was higher in non-vaccinated groups, increasing vulnerability to malignant arrhythmias and sudden death. High left ventricular volume suggested a decrease in wall thickness that might lead to increased size of the heart cavity, except in the pBCSP plasmid-vaccinated dogs. There was an echocardiographic evidence of left ventricular dilation and reduction in systolic function in experimental chagasic dogs. Echocardiography allowed a more complete follow-up of the pathological process in the living patient than with other techniques like electrocardiography, anatomopathology, and histopathology, being the method of choice for characterizing the clinical stages of ChD. |
| Databáze: | OpenAIRE |
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