Characteristics, Properties and Analytical Methods for Determination of Dropropizine and Levodropropizine: A Review
| Autor: | Maximiliano da Silva Sangoi, Marina Cardoso Nemitz, Vítor Todeschini, Anna Karolina Mouzer da Silva Machado |
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| Rok vydání: | 2019 |
| Předmět: |
Drug
media_common.quotation_subject 02 engineering and technology Bioequivalence 01 natural sciences Gas Chromatography-Mass Spectrometry Analytical Chemistry Pharmacokinetics Afferent medicine Humans Levodropropizine Chromatography High Pressure Liquid media_common Chromatography Chemistry 010401 analytical chemistry Stereoisomerism 021001 nanoscience & nanotechnology 0104 chemical sciences Bioavailability Antitussive Agents Dropropizine Cough Propylene Glycols Spectrophotometry 0210 nano-technology Half-Life Tablets medicine.drug |
| Zdroj: | Critical Reviews in Analytical Chemistry. 51:174-182 |
| ISSN: | 1547-6510 1040-8347 |
| DOI: | 10.1080/10408347.2019.1700098 |
| Popis: | Dropropizine is a peripheral antitussive drug that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors. It is marketed in a racemic form or its pure enantiomer called levodropropizine and both are available worldwide in various drug dosage formulations such as tablets, sirup and oral solution. Due to the widespread use of antitussives in the clinic it is necessary to develop efficient analytical methodologies for quality control and also for pharmacokinetic, bioavailability and bioequivalence studies. This review presents a survey of the characteristics, properties and analytical methods used for drug determination, being carried out through scientific articles as well as in official compendia. From the analyzed studies, the majority reports the use of HPLC/UV techniques for drug determination, but also spectrophotometric UV/Vis methods as well as gas chromatography, and voltammetric, potentiometric and conductometric titration methods. In addition, the methodologies addressed the determination of dropropizine or levodropropizine in different types of matrices such as raw material, pharmaceutical formulations, plasma and urine. Despite the extensive clinical use of dropropizine, data from this review evidenced a still limited number of studies dealing with analytical methods for its determination in different matrices, which may be of concern since the applicability of these methods is important for quality assurance, efficacy and safety of the medicine. |
| Databáze: | OpenAIRE |
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