[Inhibin and ovarian cancer]
| Autor: | Ann E. Drummond, Henry G. Burger, Beatrice Susil, Nigel P. Groome, Tom Jobling, Peter J. Fuller, David L. Healy, Anna J. Baillie, David Robertson, Nicholas Francis Cahir, Karen Verity, Jock K. Findlay, Yan Shen, Pamela Mamers |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Serous cystadenocarcinoma Granulosa cell Immunology Ovary Nerve Tissue Proteins Granulosa cell tumour GTP-Binding Protein alpha Subunits Gi-Go Biology Follicle-stimulating hormone Internal medicine medicine Biomarkers Tumor Immunology and Allergy Humans Inhibins Aged Granulosa Cell Tumor Aged 80 and over Ovarian Neoplasms Obstetrics and Gynecology Middle Aged medicine.disease Adenocarcinoma Mucinous Immunohistochemistry female genital diseases and pregnancy complications Cystadenocarcinoma Serous Postmenopause Endocrinology medicine.anatomical_structure Reproductive Medicine Mutation Receptors FSH Female Follicle-stimulating hormone receptor Ovarian cancer |
| Zdroj: | Voprosy onkologii. 45(4) |
| ISSN: | 0507-3758 |
| Popis: | Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumours and in the majority of postmenopausal women with mucinous ovarian cancers. The present manuscript confirms these findings in a larger group of postmenopausal women. Immunohistochemistry for the inhibin α , β A and β B subunits shows predominantly epithelial staining in granulosa cell tumours and in the majority of mucinous cancers. Serous cystadenocarcinomas also frequently show positive staining. Studies seeking to identify G α i-2 or FSH receptor mutations have provided negative results in contrast to other reports. Further studies of the roles of the inhibin-related family of peptides in ovarian cancer diagnosis and monitoring are clearly indicated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|