The effect of exercise and in vivo treatment with ACTH and norepinephrine on the lipolytic responsiveness of guinea pig (Cavia porcellus) adipose tissue
| Autor: | Ryno J. Naudé, Ryno Van den Bergh, Willem Oelofsen, Stephanus E. Terblanche |
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| Rok vydání: | 1992 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Physiology Lipolysis Guinea Pigs Adipose tissue Cavia Physical exercise Biology In Vitro Techniques Biochemistry Guinea pig Norepinephrine (medication) Norepinephrine Adrenocorticotropic Hormone In vivo Internal medicine Physical Conditioning Animal medicine Animals Molecular Biology General Medicine biology.organism_classification Kinetics Endocrinology Adipose Tissue Catecholamine medicine.drug |
| Zdroj: | Comparative biochemistry and physiology. B, Comparative biochemistry. 101(4) |
| ISSN: | 0305-0491 |
| Popis: | 1. 1. In adipose slices of the guinea pig (Cavia porcellus), adrenocorticotrophic hormone (ACTH) produced a significantly higher lipolytic response (increased V max and decreased K m ) as compared to norepinephrine (NE), thus indicating a marked difference with human adipose tissue. 2. 2. Exercise-training caused a significant increase in the affinity of the lipolytic response in adipose tissue towards both ACTH and NE, but had no significant effect on V max . 3. 3. Prolonged in vivo treatment with both ACTH and NE significantly decreased the responsiveness (affinity and capacity) of adipose slices towards ACTH. Responsiveness towards NE was much less affected. |
| Databáze: | OpenAIRE |
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