The duodenal mucosa associated microbiome, visceral sensory function, immune activation and psychological comorbidities in functional gastrointestinal disorders with and without self-reported non-celiac wheat sensitivity

Autor:	Ayesha Shah, Seungha Kang, Nicholas J Talley, Anh Do, Marjorie M Walker, Erin R Shanahan, Natasha A Koloski, Michael P Jones, Simon Keely, Mark Morrison, Gerald J Holtmann
Rok vydání:	2022
Předmět:	Microbiology (medical) Infectious Diseases Gastrointestinal Diseases Sensation Gastroenterology Humans Wheat Hypersensitivity Self Report Intestinal Mucosa Microbiology Gastrointestinal Microbiome
Zdroj:	Gut Microbes. 14
ISSN:	1949-0984 1949-0976
Popis:	Frequently, patients with functional gastrointestinal disorders (FGIDs) report intolerance of wheat products. We compared gastrointestinal symptoms, sensory function, psychiatric comorbidities, gut-homing immune cells, and duodenal mucosa-associated microbiome (d-MAM) in FGID patients and controls with and without self-reported wheat sensitivity (SR-NCWS). We recruited 40 FGID patients and 20 controls referred by GPs for treatment. Gastrointestinal/extraintestinal symptoms, visceral sensory function, psychological comorbidities, and SR-NCWS were assessed in a standardized approach. Peripheral gut homing T-cells (CD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfa9f93b060b5a139d279b8a20665b8 https://doi.org/10.1080/19490976.2022.2132078 Zobrazit plný text záznamu