IFN-gamma production and astrocyte recognition by autoreactive T cells induced by Theiler's virus infection: role of viral strains and capsid proteins
| Autor: | Mikako Kobayashi-Warren, Robert S. Fujinami, Ikuo Tsunoda, Jane E. Libbey |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
viruses
CD8 Antigens Immunology Enzyme-Linked Immunosorbent Assay medicine.disease_cause Virus Cell Line Interferon-gamma Mice Interferon Theilovirus Cricetinae medicine Immunology and Allergy Cytotoxic T cell Animals Antigen-presenting cell biology Models Immunological virus diseases biology.organism_classification Virology nervous system diseases Killer Cells Natural Cardiovirus Molecular mimicry Neurology Capsid Cytokines Capsid Proteins Female Neurology (clinical) CD8 Spleen medicine.drug T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of neuroimmunology. 172(1-2) |
| ISSN: | 0165-5728 |
| Popis: | From mice infected with the DA strain of Theiler’s murine encephalomyelitis virus (TMEV), CD8 + cytotoxic T lymphocytes (CTLs) could be detected after stimulation with TMEV infected antigen presenting cells (APCs). These CTLs killed not only TMEV infected but also uninfected syngeneic cells. Killing was associated with interferon (IFN)-g production in ELISPOTassays. The CTLs were efficiently induced by vaccinia virus encoding DA virus capsid proteins, but not by APCs infected with the GDVII strain of TMEV. The CTLs produced IFN-g in response to TMEV infected, but not uninfected, astrocytes. The CTLs could be maintained in the presence of interleukin (IL)-2. We hypothesized that, in DA virus infection, CD8 + CTLs specific for viral capsid protein could recognize self protein on oligodendrocytes by molecular mimicry, leading to demyelination. D 2005 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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