A clinical evaluation of the effects of topically applied levobunolol and timolol on increased intraocular pressure
| Autor: | Irving H. Leopold, Amin Scharrer, Efraim Duzman, Manuel Ober |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Intraocular pressure Time Factors genetic structures Administration Topical Levobunolol Timolol Glaucoma Ocular hypertension Blood Pressure Propanolamines Double-Blind Method Heart rate medicine Humans Intraocular Pressure Aged Clinical Trials as Topic business.industry medicine.disease eye diseases Ophthalmology Blood pressure Anesthesia Female business Clinical evaluation Glaucoma Open-Angle medicine.drug |
| Zdroj: | American journal of ophthalmology. 94(3) |
| ISSN: | 0002-9394 |
| Popis: | Data from two short-term double-masked studies using 24 and 16 subjects suggest that topically applied levobunolol safely and effectively treats open-angle glaucoma and ocular hypertension. The onset of effect of a single drop of 0.5% levobunolol occurred within the first hour, producing a maximal hypotensive effect of more than 8 mm Hg after two hours. An intraocular pressure deceased of greater than or equal to 2 mm Hg was still observed after 24 hours for both concentrations of levobunolol tested (0.5% and 1%). Intraocular pressure decreases of more than 9 mm Hg persisted during a one-month trial in which patients were treated twice daily, confirming the results obtained in the 24-hour study. Systemic effects of both timolol (0.5%) and levobunolol (0.5% and 1%) included a consensual intraocular pressure-decreasing effect in the untreated eye and clinically significant reductions in heart rate. Diastolic blood pressure was decreased at two and four hours after administration of 0.5% levobunolol. |
| Databáze: | OpenAIRE |
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