Voluntary consumption of substances of unknown palatability by vervet monkeys: a refinement
| Autor: | A. Davids, T. Collop, J.V. Seier, R. Laubscher, M. Mdhluli |
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| Rok vydání: | 2008 |
| Předmět: |
Dosage Forms
Male Consumption (economics) Food intake General Veterinary Metabolite Food consumption Administration Oral Feeding Behavior Biology Animal Feed Maize meal chemistry.chemical_compound Pharmaceutical Preparations chemistry Turnover Chlorocebus aethiops Animals Female Animal Science and Zoology Plant Preparations Palatability Food science Habituation |
| Zdroj: | Journal of Medical Primatology. 37:88-92 |
| ISSN: | 1600-0684 0047-2565 |
| DOI: | 10.1111/j.1600-0684.2007.00231.x |
| Popis: | Background Pure compounds and herbal medicines, had to be administered orally to vervet monkeys for testing. A reliable method was sought to avoid daily gavaging. Methods Substances were incorporated into the maize meal based diet of this facility for voluntary consumption. Food intake was monitored. Results In all but one case, consumption of the treated food was in excess of 90%. In all cases, the purpose of the study was achieved. Habituation was usually only required to the vehicle, and was accomplished by incremental increases to the desired concentration. Aversion was overcome by the addition of a small amount of honey. Plasma concentrations of a compound metabolite could be measured in one case after gavage and food consumption, and were similar for both methods. Conclusion The method enables reliable voluntary consumption of diverse substances. Since stressful gavaging is avoided, it is a valuable contribution to the 3Rs. |
| Databáze: | OpenAIRE |
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