Synthesis and biological evaluation of novel 2,4-disubstituted-1,3-thiazoles as anti-Candida spp. agents
| Autor: | Bruna Bizzarri, Daniela Rivanera, D. Lilli, Simone Carradori, Melissa D'Ascenzio, Adriana Bolasco, Daniela Secci, Franco Chimenti, Arianna Granese, Paola Chimenti |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Antifungal Agents
Stereochemistry Drug Evaluation Preclinical Hydrazone Microbial Sensitivity Tests Chemical synthesis chemistry.chemical_compound candida spp hantzsch reaction hydrazone thiazole Drug Discovery medicine Moiety Candida albicans Thiazole Candida Pharmacology chemistry.chemical_classification biology Candida glabrata Bicyclic molecule Chemistry Clotrimazole Organic Chemistry General Medicine biology.organism_classification Thiazoles medicine.drug |
| Zdroj: | European Journal of Medicinal Chemistry. 46:378-382 |
| ISSN: | 0223-5234 |
| Popis: | A new series of [4-(4′-substituted-phenyl)thiazol-2-yl]hydrazine derivatives were synthesized in good yield (86–99%) and characterized by elemental analysis, IR, 1 H NMR, and mass spectral studies. The compounds were assayed for their in vitro broad-spectrum antifungal activity, compared to clotrimazole and fluconazole, against 20 clinical isolates of pathogenic Candida spp., representing five different species. The results showed that the presence of heterocyclic or bicyclic rings on hydrazone moiety in position C2 of thiazole revealed a promising selective inhibitory activity especially against Candida albicans and Candida glabrata . |
| Databáze: | OpenAIRE |
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