Comparison between a new 13C-urea breath test, using a film-coated tablet, and the conventional 13C-urea breath test for the detection of Helicobacter pylori infection
| Autor: | Masahiro Asaka, Katsutoshi Obara, Ryuichi Nagashima, Shiro Hamada, Takayoshi Toyota, Masayuki Suzuki, Chieko Kato, Mototsugu Kato, Hirohito Honda, Shuichi Ohara, Masao Saito, Shinsaku Fukuda |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Helicobacter pylori infection medicine.medical_specialty Urease Urea breath test Stomach Diseases Gastroenterology Sensitivity and Specificity 13C urea breath test Helicobacter Infections chemistry.chemical_compound Internal medicine medicine Ingestion Humans Urea Duodenal Diseases Aged Aged 80 and over Carbon Isotopes Cross-Over Studies Film-coated tablet biology medicine.diagnostic_test Helicobacter pylori business.industry digestive oral and skin physiology Middle Aged biology.organism_classification Solutions chemistry Breath Tests biology.protein Female business Tablets |
| Zdroj: | Journal of gastroenterology. 39(7) |
| ISSN: | 0944-1174 |
| Popis: | In Japan, urea breath-testing includes mouth rinsing with water immediately after the ingestion of (13)C-urea solution, to prevent false-positive results that are caused by oral bacteria with urease activity. Our objective was to evaluate the diagnostic performance of a urea breath test using a film-coated (13)C-urea tablet and omitting mouth rinsing.The study was a multicenter trial comparing the solution- and tablet-based urea breath tests (UBTs). Helicobacter pylori status was determined by histology, culture, and rapid urease testing.Of the 255 subjects who completed the study, evaluation of the tablet-based UBT was possible in 254, and comparison of the tablet-based UBT and the solution-based UBT was possible in 250 patients. When the assessment achieved by a combination of biopsy-based methods was used as a reference standard, the sensitivity, specificity, and accuracy of the tablet-based method were determined to be 97.7%, 98.4%, and 98.0%, respectively. When the results of the solution-based UBT were used as a reference standard, the sensitivity, specificity, and accuracy of the tablet-based UBT were determined to be 96.9%, 97.6%, and 97.2%, respectively.The (13)C-urea tablet-based method proved to be a simple and accurate test for the diagnosis of H. Pylori infection. Mouth rinsing was not required. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink