Ultrasound Measures of Brain Pulsatility Correlate with Subcortical Brain Volumes in Healthy Young Adults
| Autor: | Paul-Armand Dujardin, Valérie Gissot, Bruno Brizard, Frédéric Patat, Thomas Desmidt, Jean-Philippe Cottier, Wissam El-Hage, Jean-Pierre Remenieras, Vincent Camus, Frédéric Andersson |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Acoustics and Ultrasonics Ultrasonography Doppler Transcranial Biophysics Caudate nucleus Pulsatility index 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine Reference Values Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Young adult Ultrasonography Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Ultrasound Brain Magnetic resonance imaging Organ Size Middle Aged Transcranial Doppler Cerebral blood flow Cerebrovascular Circulation Pulsatile Flow Brain size Cardiology Female France business Blood Flow Velocity 030217 neurology & neurosurgery |
| Zdroj: | Ultrasound in Medicine & Biology. 44:2307-2313 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2018.06.016 |
| Popis: | Increasing evidence suggests that brain pulsatility is involved in the pathophysiology of various neurological and psychiatric disorders. However, it remains unclear whether high brain pulsatility is damaging to or protective of the brain in normal conditions, and this could depend on the age of the individual and the methods used to measure brain pulsatility. The goal of our study was to investigate associations between subcortical volumes and brain pulsatility as assessed with ultrasound in healthy young adults using both a conventional method (transcranial Doppler pulsatility index [TCD-PI]) and the innovative method of tissue pulsatility imaging (TPI), which allows a high level of detection of small brain movements (micrometers). Twenty-five females aged 18–55 with no history of significant medical disorder underwent magnetic resonance imaging and ultrasound assessment. The volumes of six subcortical regions known to be particularly sensitive to change in cerebral blood flow were measured and compared with brain pulsatility as assessed with TCD-PI and TPI. TCD-PI and TPI measures positively correlated with all subcortical regions, with the caudate nucleus having the strongest association. Linear regressions found that TCD-PI and TPI measures of brain pulsatility explained 16% to 67% of the variance of the subcortical volumes. Our results suggest that a greater pulsatility as assessed with ultrasound in healthy young adults may constitute a protective factor for brain structure. Ultrasound measures of brain pulsatility may be appropriate to provide costless, non-invasive, portable and highly sensitive markers of cerebral blood flow pulsatility related to brain structure. |
| Databáze: | OpenAIRE |
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