Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: a replication study
| Autor: | J. Biurrun-Manresa, E. N. van den Broeke, Diana Torta, Alexandre Stouffs, T. Vanmaele, André Mouraux |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
C-FIBER
MECHANICAL HYPERALGESIA Stimulation Biology FREQUENCY ELECTRICAL-STIMULATION 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Psychology and Cognitive Neuroscience Replication (statistics) 0501 psychology and cognitive sciences high-frequency stimulation ALPHA(2)-ADRENOCEPTORS lcsh:Science long-term potentiation Replications Multidisciplinary Science & Technology High frequency stimulation integumentary system INDUCTION 05 social sciences Long-term potentiation SECONDARY HYPERALGESIA humanities Peripheral body regions Multidisciplinary Sciences homotopic hyperalgesia PAIN AMPLIFICATION Nociception HUMAN SKIN Science & Technology - Other Topics lcsh:Q Animal studies LTP Neuroscience 030217 neurology & neurosurgery RESPONSES |
| Zdroj: | Royal Society Open Science Royal Society Open Science, Vol 8, Iss 1 (2021) |
| Popis: | Animal studies have shown that high-frequency stimulation (HFS) of peripheral C-fibres induces long-term potentiation (LTP) within spinal nociceptive pathways. The aim of this replication study was to assess if a perceptual correlate of LTP can be observed in humans. In 20 healthy volunteers, we applied HFS to the left or right volar forearm. Before and after applying HFS, we delivered single electrical test stimuli through the HFS electrode while a second electrode at the contra-lateral arm served as a control condition. Moreover, to test the efficacy of the HFS protocol, we quantified changes in mechanical pinprick sensitivity before and after HFS of the skin surrounding both electrodes. The perceived intensity was collected for both electrical and mechanical stimuli. After HFS, the perceived pain intensity elicited by the mechanical pinprick stimuli applied on the skin surrounding the HFS-treated site was significantly higher compared to control site (heterotopic effect). Furthermore, we found a higher perceived pain intensity for single electrical stimuli delivered to the HFS-treated site compared to the control site (homotopic effect). Whether the homotopic effect reflects a perceptual correlate of homosynaptic LTP remains to be elucidated. ispartof: ROYAL SOCIETY OPEN SCIENCE vol:8 issue:1 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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