Cutaneous epithelioid angiomatous nodule: a report of a series including a case with moderate cytologic atypia and immunosuppression

Autor: Ayman Al Habeeb, Danny Ghazarian, Ami Wang, Runjan Chetty, Zaid Saeed Kamil
Rok vydání: 2018
Předmět:
Male
Pathology
Neoplasm
Residual
Skin Neoplasms
medicine.medical_treatment
Biopsy
Mitotic Count
030207 dermatology & venereal diseases
0302 clinical medicine
Clinical history
Atypia
Vascular tumour
Cytologic atypia
Epithelioid Cells
Immunosuppression
General Medicine
Middle Aged
medicine.anatomical_structure
Treatment Outcome
030220 oncology & carcinogenesis
Female
medicine.symptom
Hemangioma
Epithelioid cell
Immunosuppressive Agents
lcsh:RB1-214
Adult
medicine.medical_specialty
Histology
Adolescent
Pathology and Forensic Medicine
Diagnosis
Differential
03 medical and health sciences
Immunocompromised Host
Young Adult
Dermis
Predictive Value of Tests
medicine
lcsh:Pathology
Mitotic Index
Humans
Cell Proliferation
Retrospective Studies
Angiomatous nodule
business.industry
Research
Nodule (medicine)
Epithelioid
medicine.disease
Cutaneous
Neoplasm Recurrence
Local
business
Zdroj: Diagnostic Pathology
Diagnostic Pathology, Vol 13, Iss 1, Pp 1-5 (2018)
ISSN: 1746-1596
Popis: Background Cutaneous epithelioid angiomatous nodule (CEAN) is a very rare and relatively recently recognized vascular proliferation characterized usually by minimal cytological atypia and accompanying mitotic activity. As such, CEAN represents an important diagnostic pitfall, which could lead to significant misdiagnosis and unnecessary treatment. Methods The clinicopathologic findings of 5 cases of CEAN were reviewed including a unique case with typical findings but also moderate cytologic atypia and brisk mitotic activity in a patient on immunosuppression. Results The cases were in 3 women and 2 men ranging in age from 18 to 61 years with lesions in the neck (2 cases), upper arm, back and shoulder. In 4 of the cases, the patients did not have any relevant potentially contributory clinical history, and in 1 case the patient was on immunosuppressive treatment. All 5 cases were superficially located within the dermis, well-circumscribed and similarly composed of epithelioid cells displaying minimal (in 4 cases) and moderate (1 case) atypia. The mitotic count ranged from 1 to 3 per 10 high power fields (HPF) in 4 cases and up to 9 per 10 HPF in the immunosuppressed patient. Atypical mitoses were not encountered in any of the cases. Two lesions that were incompletely excised recurred, but none of the patients showed distant metastases. Conclusion While cytologically alarming, CEAN has a characteristic microscopic appearance and if completely excised follows an indolent course.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje