Neutral effect of Glioma-associated oncogene-1 expression on survival in myelofibrosis
| Autor: | Tajana Štoos-Veić, Marko Lucijanic, Zeljko Jonjic, Rajko Kusec, Marija Ivic, Katarina Marija Tupek, Amina Fazlic Dzankic, Vlatko Pejša, Ana Livun |
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| Rok vydání: | 2019 |
| Předmět: |
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030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Glioma medicine Humans Hedgehog Proteins 030212 general & internal medicine Myelofibrosis Survival analysis Retrospective Studies Oncogene business.industry General Medicine medicine.disease Hedgehog signaling pathway medicine.anatomical_structure Primary Myelofibrosis Cancer research Bone marrow Smoothened business Signal Transduction |
| Zdroj: | Wiener klinische Wochenschrift. 132(15-16) |
| ISSN: | 1613-7671 |
| Popis: | This study retrospectively analyzed glioma-associated oncogene 1 (GLI‑1) mRNA expression in unfractionated bone marrow aspirates of 32 patients with myelofibrosis and 16 controls. It was found that GLI‑1 expression did not significantly differ between primary, secondary myelofibrosis and controls (median difference in threshold cycles ∆CT 7.2, 7.3 and 6.9, respectively; P = 0.864), as well as that survival curves of myelofibrosis patients with higher/lower GLI‑1 expression showed multiple overlaps and overall comparable course (P = 0.651). The results suggest that general upregulation of GLI‑1 does not seem to be a feature of the disease and are in line with modest biological and clinical effects observed with inhibitors of Hedgehog signaling pathway in patients with myelofibrosis. |
| Databáze: | OpenAIRE |
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