Emergent modular neural control drives coordinated motor actions
| Autor: | Stefan M. Lemke, Ling Guo, Dhakshin S. Ramanathan, Seok Joon Won, Karunesh Ganguly |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Nervous system Patch-Clamp Techniques Computer science Models Neurological education Action Potentials Article 03 medical and health sciences 0302 clinical medicine Forelimb Basal ganglia Biological neural network medicine Animals Learning Muscimol Movement (music) General Neuroscience Motor Cortex Motor control Corpus Striatum Rats 030104 developmental biology medicine.anatomical_structure Action (philosophy) Motor Skills Conditioning Operant Intracranial Thrombosis Primary motor cortex Reinforcement Psychology Neuroscience Psychomotor Performance 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/s41593-019-0407-2 |
| Popis: | A remarkable feature of motor control is the ability to coordinate movements across distinct body parts into a consistent, skilled action. To reach and grasp an object, 'gross' arm and 'fine' dexterous movements must be coordinated as a single action. How the nervous system achieves this coordination is currently unknown. One possibility is that, with training, gross and fine movements are co-optimized to produce a coordinated action; alternatively, gross and fine movements may be modularly refined to function together. To address this question, we recorded neural activity in the primary motor cortex and dorsolateral striatum during reach-to-grasp skill learning in rats. During learning, the refinement of fine and gross movements was behaviorally and neurally dissociable. Furthermore, inactivation of the primary motor cortex and dorsolateral striatum had distinct effects on skilled fine and gross movements. Our results indicate that skilled movement coordination is achieved through emergent modular neural control. |
| Databáze: | OpenAIRE |
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