The mechanics of ribosomal translocation
| Autor: | John Achenbach, Knud H. Nierhaus |
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| Rok vydání: | 2015 |
| Předmět: |
Models
Molecular Messenger RNA Molecular Sequence Data Hydrogen Bonding Translation (biology) General Medicine Ribosomal RNA Biology Peptide Elongation Factor G Biochemistry Ribosome Molecular biology Cell biology RNA Transfer Catalytic Domain Protein Biosynthesis Protein biosynthesis Animals Humans Amino Acid Sequence RNA Messenger T arm Ribosomes Peptide sequence |
| Zdroj: | Biochimie. 114:80-89 |
| ISSN: | 0300-9084 |
| Popis: | The ribosome translates the sequence of codons of an mRNA into the corresponding sequence of amino acids as it moves along the mRNA with a codon-step width of about 10 Å. The movement of the million-dalton complex ribosome is triggered by the universal elongation factor G (EF2 in archaea and eukaryotes) and is termed translocation. Unraveling the molecular details of translocation is one of the most challenging tasks of current ribosome research. In the last two years, enormous progress has been obtained by highly-resolved X-ray and cryo-electron microscopic structures as well as by sophisticated biochemical approaches concerning the trigger and control of the movement of the tRNA2·mRNA complex inside the ribosome during translocation. This review inspects and surveys these achievements. |
| Databáze: | OpenAIRE |
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