Smart Self‐Assembly Amphiphilic Cyclopeptide‐Dye for Near‐Infrared Window‐II Imaging
| Autor: | Hongyue Lou, Mark Zhu, Yuebing Wang, Si Chen, Kun Qian, Zhen Cheng, Ling Tong, Zhenhua Hu, Jie Tian, Bingbing Ding, Kangquan Shou, Dean W. Felsher, Aiyan Ji, Alexander Hsu, Zhiming Wang, Lei Jiang, Hao Chen, Chunrong Qu |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Mechanical Engineering Optical Imaging Near-infrared spectroscopy Nanoprobe Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Peptides Cyclic 01 natural sciences Fluorescence Small molecule 0104 chemical sciences Nanomaterials Mice Mechanics of Materials Animals General Materials Science Self-assembly Molecular imaging 0210 nano-technology Fluorescent Dyes |
| Zdroj: | Advanced Materials. 33:2006902 |
| ISSN: | 1521-4095 0935-9648 1000-1700 |
| Popis: | Development of novel nanomaterials for disease theranostics represents an important direction in chemistry and precision medicine. Fluorescent molecular probes in the second near-infrared window (NIR-II, 1000-1700 nm) show high promise because of their exceptional high detection sensitivity, resolution, and deep imaging depth. Here, a sharp pH-sensitive self-assembling cyclopeptide-dye, SIMM1000, as a smart nanoprobe for NIR-II imaging of diseases in living animals, is reported. This small molecule assembled nanoprobe exhibits smart properties by responding to a sharp decrease of pH in the tumor microenvironment (pH 7.0 to 6.8), aggregating from small nanoprobe (80 nm at pH 7.0) into large nanoparticles (>500 nm at pH 6.8) with approximate to 20-30 times enhanced fluorescence compared with the non-self-assembled CH-4T. It yields micrometer-scale resolution in blood vessel imaging and high contrast and resolution in bone and tumor imaging in mice. Because of its self-aggregation in acidic tumor microenvironments in situ, SIMM1000 exhibits high tumor accumulation and extremely long tumor retention (>19 days), while being excretable from normal tissues and safe. This smart self-assembling small molecule strategy can shift the paradigm of designing new nanomaterials for molecular imaging and drug development. |
| Databáze: | OpenAIRE |
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