Botulinum toxin A treatment for post-herpetic neuralgia: A systematic review and meta-analysis
| Autor: | Zhen Zeng, Li‑Lei Peng, Xu Zeng, Hai‑Ping He, Xin‑Long Li, Li‑Gang Chen, Shan Zeng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
safety Cancer Research medicine.medical_specialty Lidocaine Visual analogue scale efficacy Cochrane Library law.invention 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) Randomized controlled trial law Internal medicine medicine post-herpetic neuralgia Adverse effect botulinum toxin-a business.industry General Medicine Articles medicine.disease meta-analysis 030104 developmental biology McGill Pain Questionnaire 030220 oncology & carcinogenesis Meta-analysis Neuralgia business medicine.drug |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-0981 |
| Popis: | The present meta-analysis study aimed to investigate the safety and efficacy of local administration of botulinum toxin (BTX-A) vs. lidocaine in the treatment of post-herpetic neuralgia. A systematic search of the Cochrane Library, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, Chongqing VIP Information Co. and Chinese Biomedical Literature Database was performed to identify randomized controlled trials (RCTs) comparing BTX-A and lidocaine in the treatment of post-herpetic neuralgia. The primary outcomes were Visual Analogue Scale (VAS) pain scores at 1, 2 and 3 months after treatment and the effective rate. Secondary outcomes were scores on the McGill pain questionnaire and adverse event rate. A total of 7 RCTs comprising 752 patients were included. The VAS pain score was significantly lower at 1 month [mean difference (MD)=-2.31; 95% CI: -3.06, -1.56; P |
| Databáze: | OpenAIRE |
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