Differences in the frequencies of HLA-class I and II alleles between German patients with renal cell carcinoma and healthy controls
| Autor: | Steffen Goebel, Sven Wach, Gerald Schlaf, Bernd Wullich, Kersten Fischer, Astrid Kehlen, Karen Bluemke, Helge Taubert, Wolfgang Altermann, Paolo Fornara |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Immunology Human leukocyte antigen HLA-C Antigens Biology 03 medical and health sciences 0302 clinical medicine Gene Frequency Renal cell carcinoma Germany HLA-B Antigens medicine Immunology and Allergy Humans Allele Allele frequency Carcinoma Renal Cell Aged Aged 80 and over Predictive marker HLA-A Antigens Histocompatibility Antigens Class I Histocompatibility Antigens Class II HLA-DR Antigens Middle Aged medicine.disease Prognosis Kidney Neoplasms Exact test 030104 developmental biology Oncology Tumor progression 030220 oncology & carcinogenesis Case-Control Studies Female |
| Zdroj: | Cancer immunology, immunotherapy : CII. 66(5) |
| ISSN: | 1432-0851 |
| Popis: | The human leukocyte antigen (HLA) system is a major part of the human immune system and has an impact on tumor initiation, tumor progression, and immunosurveillance. Renal cell carcinoma tumors are considered to be immunogenic. Therefore, we studied the allele frequencies of four gene loci (HLA-A, -B, -C, and HLA-DR) in a cohort of German renal cell carcinoma (RCC) patients and in healthy controls. HLA-A-C were determined using serological methods, whereas HLA-C12, C14, C16, C18, and HLA-DR were characterized through the use of standard molecular biological methods. The occurrence of the HLA-C*12 allele was significantly increased in German RCC patients compared with healthy controls (P |
| Databáze: | OpenAIRE |
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