Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects

Autor: Claudia Mundt, Jan Batzer, Karen Torn Dieck, Roger I. Ceilley, Horst Wenck, Jeannine Immeyer, Rainer Wolber, Uwe Schönrock, Ursula Wensorra, Ludger Kolbe, Franz Stäb
Rok vydání: 2006
Předmět:
Zdroj: Archives of Dermatological Research. 298:23-30
ISSN: 1432-069X
0340-3696
DOI: 10.1007/s00403-006-0654-4
Popis: Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-controlled clinical trials to assess the anti-irritative efficacy of cosmetic formulations containing LicA in a post-shaving skin irritation model and on UV-induced erythema formation. The clinical trials were accompanied by a series of in vitro experiments to characterize anti-inflammatory properties of LicA on several dermatologically relevant cell types. Topical LicA causes a highly significant reduction in erythema relative to the vehicle control in both the shave- and UV-induced erythema tests, demonstrating the anti-irritative properties of LicA. Furthermore, LicA is a potent inhibitor of pro-inflammatory in vitro responses, including N-formyl-MET-LEU-PHE (fMLP)- or zymosan-induced oxidative burst of granulocytes, UVB-induced PGE(2) release by keratinocytes, lipopolysaccharide (LPS)-induced PGE(2) release by adult dermal fibroblasts, fMLP-induced LTB(4) release by granulocytes, and LPS-induced IL-6/TNF-alpha secretion by monocyte-derived dendritic cells. The reported data suggest therapeutic skin care benefits from LicA when applied to sensitive or irritated skin.
Databáze: OpenAIRE
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