Innate immunity in lung transplantation
| Autor: | Hailey M. Shepherd, Andrew E. Gelman, Wenjun Li, Daniel Kreisel, Jason M. Gauthier, Alexander S. Krupnick |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Graft Rejection
0301 basic medicine Pulmonary and Respiratory Medicine Programmed cell death Graft failure medicine.medical_treatment Primary Graft Dysfunction Inflammation 030230 surgery Lung injury 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Lung transplantation Transplantation Innate immune system business.industry respiratory system Immunity Innate surgical procedures operative 030104 developmental biology Immunology Surgery medicine.symptom Cardiology and Cardiovascular Medicine business Lung Transplantation |
| Zdroj: | The Journal of Heart and Lung Transplantation. 40:562-568 |
| ISSN: | 1053-2498 |
| DOI: | 10.1016/j.healun.2021.03.017 |
| Popis: | Innate immune pathways early after pulmonary transplantation have been shown to cause primary graft dysfunction (PGD) and also predispose to late graft failure. Recent studies in animal models have elucidated critical mechanisms governing such innate immune responses. Here, we discuss pathways of inflammatory cell death, triggers for sterile and infectious inflammation, and signaling cascades that mediate lung injury early after transplantation. These studies highlight potential avenues for lung-specific therapies early following lung transplantation to dampen innate immune responses and improve outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|