Moxifloxacin-containing regimen greatly reduces time to culture conversion in murine tuberculosis
| Autor: | Jacques H. Grosset, Andrew N. Vernon, Eric L. Nuermberger, William R. Bishai, Tetsuyuki Yoshimatsu, Richard E. Chaisson, Sandeep Tyagi, Richard J. O'Brien |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Tuberculosis Time Factors Moxifloxacin SQ109 Antitubercular Agents Biological Availability Microbial Sensitivity Tests Critical Care and Intensive Care Medicine Sensitivity and Specificity Mycobacterium tuberculosis chemistry.chemical_compound Mice Internal medicine Intensive care medicine Culture conversion Animals Probability Analysis of Variance Aza Compounds Mice Inbred BALB C biology business.industry Pyrazinamide biology.organism_classification medicine.disease Culture Media Regimen Disease Models Animal Treatment Outcome chemistry Immunology Quinolines Drug Therapy Combination Female business medicine.drug Fluoroquinolones |
| Zdroj: | American journal of respiratory and critical care medicine. 169(3) |
| ISSN: | 1073-449X |
| Popis: | Tuberculosis continues to be a major cause of morbidity and mortality in the world. The expansion of tuberculosis control programs has been limited by the lengthy and cumbersome nature of current chemotherapeutic regimens. A new drug that improves the sterilizing activity of current regimens would reduce the duration of therapy without sacrificing efficacy, thereby enhancing treatment completion rates and preserving precious public health resources. The new 8-methoxyfluoroquinolone moxifloxacin has potent activity against both actively multiplying and nonactively multiplying tubercle bacilli. Using a murine model that is representative of chemotherapy for human tuberculosis, we show that the combination of moxifloxacin, rifampin, and pyrazinamide reduced the time needed to eradicate Mycobacterium tuberculosis from the lungs of infected mice by up to 2 months when compared with the standard regimen of isoniazid, rifampin, and pyrazinamide. The findings suggest that this regimen has the potential to substantially shorten the duration of therapy needed to cure human tuberculosis. |
| Databáze: | OpenAIRE |
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