Dermal absorption of semivolatile organic compounds from the gas phase: Sensitivity of exposure assessment by steady state modeling to key parameters

Autor: Fabien Mercier, Corinne Mandin, Philippe Glorennec, Nathalie Bonvallot, Maud Pelletier, Olivier Ramalho, Barbara Le Bot, Olivier Blanchard
Přispěvatelé: Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), École des Hautes Études en Santé Publique [EHESP] ( EHESP ), Centre Scientifique et Technique du Bâtiment ( CSTB ), Laboratoire d'étude et de recherche en environnement et santé ( LERES ), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Scientifique et Technique du Bâtiment (CSTB), Institut National de l'Environnement Industriel et des Risques (INERIS), Glorennec, Philippe, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Octanol
010504 meteorology & atmospheric sciences
Skin Absorption
Chemical
indoor air
Semivolatile organic compounds
010501 environmental sciences
01 natural sciences
[ SDV.EE.SANT ] Life Sciences [q-bio]/Ecology
environment/Health
chemistry.chemical_compound
Phase (matter)
Contact
Humans
Organic matter
Particle density
Monte Carlo
lcsh:Environmental sciences
0105 earth and related environmental sciences
General Environmental Science
Exposure assessment
Percutaneous
lcsh:GE1-350
chemistry.chemical_classification
Air Pollutants
Volatile Organic Compounds
Models
Theoretical
Partition coefficient
chemistry
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
13. Climate action
Air Pollution
Indoor
Environmental chemistry
Particle
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Gases
Steady state (chemistry)
Sensitivity analysis
Monte Carlo Method
Zdroj: Environment International
Environment International, Elsevier, 2017, 102, pp.106-113. 〈10.1016/j.envint.2017.02.005〉
Environment International, 2017, 102, pp.106-113. ⟨10.1016/j.envint.2017.02.005⟩
Environment International, Elsevier, 2017, 102, pp.106-113. ⟨10.1016/j.envint.2017.02.005⟩
Environment International, Vol 102, Iss, Pp 106-113 (2017)
ISSN: 0160-4120
Popis: Recent research has demonstrated the importance of dermal exposure for some semivolatile organic compounds (SVOCs) present in the gas phase of indoor air. Though models for estimating dermal intake from gaseous SVOCs exist, their predictions can be subject to variations in input parameters, which can lead to large variation in exposure estimations. In this sensitivity analysis for a steady state model, we aimed to assess these variations and their determinants using probabilistic Monte Carlo sampling for 8 SVOCs from different chemical families: phthalates, bisphenols, polycyclic aromatic hydrocarbons (PAHs), organophosphorus (OPs), organochlorines (OCs), synthetic musks, polychlorinated biphenyls (PCBs) and polybromodiphenylethers (PBDEs). Indoor SVOC concentrations were found to be the most influential parameters. Both Henry's law constant (H) and octanol/water partition coefficient (Kow) uncertainty also had significant influence. While exposure media properties such as volume fraction of organic matter in the particle phase (fom-part), particle density (ρpart), concentration ([TSP]) and transport coefficient (ɣd) had a slight influence for some compounds, human parameters such as body weight (W), body surface area (A) and daily exposure (t) make a marginal or null contribution to the variance of dermal intake for a given age group. Inclusion of a parameter sensitivity analysis appears essential to reporting uncertainties in dermal exposure assessment. Keywords: Percutaneous, Indoor air, Chemical, Contact, Sensitivity analysis, Monte Carlo
Databáze: OpenAIRE
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