Short and long-term changes in platelet and inflammatory biomarkers after cryoballoon and radiofrequency ablation

Autor: De Greef Yves, Riccardo Cappato, Bailing Dai, Shulin Wu, Xiaolei Yang, Zhao Wang, Lili Wang, Gary Tse, Yunlong Xia, Khalid Bin Waleed, Xiaomeng Yin, Lianjun Gao, Yang Liu, Xumin Guan
Přispěvatelé: Clinical sciences, Heartrhythmmanagement
Rok vydání: 2019
Předmět:
Inflammation/blood
Blood Platelets
Male
medicine.medical_specialty
Time Factors
Radiofrequency ablation
medicine.medical_treatment
030204 cardiovascular system & hematology
Cryosurgery
Platelet Activation/physiology
law.invention
Heart Conduction System/physiopathology
03 medical and health sciences
0302 clinical medicine
Heart Conduction System
law
Internal medicine
Atrial Fibrillation
Humans
Medicine
Sinus rhythm
Platelet
Postoperative Period
030212 general & internal medicine
Platelet activation
Mean platelet volume
Retrospective Studies
Cryosurgery/methods
Inflammation
business.industry
Platelet Distribution Width
Atrial fibrillation
Middle Aged
Platelet Activation
medicine.disease
Ablation
Catheter Ablation/methods
Atrial Fibrillation/blood
Catheter Ablation
Cardiology
Female
Blood Platelets/metabolism
Cardiology and Cardiovascular Medicine
business
Biomarkers/blood
Biomarkers
Follow-Up Studies
Zdroj: International Journal of Cardiology. 285:128-132
ISSN: 0167-5273
DOI: 10.1016/j.ijcard.2019.02.054
Popis: BACKGROUND: Cryoballoon (CB) versus radiofrequency (RF) ablation response on prothrombotic biomarkers obtained different results at short-term, while long-term is still unknown in atrial fibrillation (AF) treatment. We evaluated short and long-term changes in platelet and inflammatory biomarkers after CB and RF ablation. METHODS: Fifty-eight paroxysmal AF patients were randomized for pulmonary vein (PV) isolation using either CB (n = 29) or RF (n = 29) ablation. Biomarkers of platelet activation [P-selectin (CD62P), CD40 ligand (CD40L), platelet factor-4 (PF-4), mean platelet volume (MPV), platelet-leukocyte ratio (P-LCR), and platelet distribution width (PDW)]; and inflammatory [high sensitivity CRP (hs-CRP) and interleukin-6 (IL-6)] were measured at baseline, 18-24 h and 6-Months postablation. RESULTS: Twenty-four (86.2%) and twenty-six (89.7%) patients remained in sinus rhythm at 6-Months in CB and RF group respectively (p = 0.500). After 18-24 h postablation, CD62P, CD40L, PF-4, hs-CRP, and IL-6 levels were significantly activated in both groups (p 0.05) compared to baseline levels. hs-CRP and IL-6 levels were comparable between baseline and 6-Months in both groups (p > 0.05). CONCLUSIONS: CB ablation might influence the risk of thromboembolism due to less platelet activation after PV isolation and decreased platelet activation at long-term in maintained sinus rhythm patients compared to RF.
Databáze: OpenAIRE
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