Antineutrophil cytoplasmic antibody–negative pauci-immune glomerulonephritis with massive intestinal bleeding
| Autor: | Miyeon Kim, So Mi Kim, Hyun Woo Kim, Sun Jin Boo, Young Uck Kim |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Vasculitis
lcsh:Internal medicine Pathology medicine.medical_specialty lcsh:Specialties of internal medicine Urology Case Report urologic and male genital diseases Gastrointestinal hemorrhage Glomerulonephritis lcsh:RC581-951 medicine lcsh:RC31-1245 Anti-neutrophil cytoplasmic antibody Intracerebral hemorrhage medicine.diagnostic_test business.industry Autoantibody medicine.disease Hematochezia Nephrology Pauci-immune Renal biopsy medicine.symptom business |
| Zdroj: | Kidney Research and Clinical Practice, Vol 34, Iss 3, Pp 180-184 (2015) Kidney Research and Clinical Practice |
| ISSN: | 2211-9132 |
| Popis: | A 61-year-old woman was admitted to hospital because of generalized edema and proteinuria. Her renal function deteriorated rapidly. Serum immunoglobulin and complement levels were within normal ranges. An autoantibody examination showed negative for antinuclear antibody and antineutrophil cytoplasmic antibody. Histologic examination of a renal biopsy specimen revealed that all of the glomeruli had severe crescent formations with no immune deposits. The patient was treated with steroid pulse therapy with cyclophosphamide followed by oral prednisolone. Fifteen days later, she experienced massive recurrent hematochezia. Angiography revealed an active contrast extravasation in a branch of the distal ileal artery. We selectively embolized with a permanent embolic agent. On the 45th hospital day, the patient suddenly lost consciousness. Brain computed tomography showed intracerebral hemorrhage. We report a case of antineutrophil cytoplasmic antibody–negative pauci-immune glomerulonephritis with massive intestinal bleeding and cerebral hemorrhage. |
| Databáze: | OpenAIRE |
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