The Disability Index of the Health Assessment Questionnaire is a predictor and correlate of outcome in the high-dose versus low-dose penicillamine in systemic sclerosis trial
| Autor: | Micha Abeles, Maureen D. Mayes, David A. Collier, Fredrick F. Wigley, Philip J. Clements, Thomas A. Medsger, Larry W. Moreland, John Varga, Virginia D. Steen, Edward V. Lally, James R. Seibold, Richard J. Martin, Brian S. Andrews, Eric L. Hurwitz, Weng Kee Wong, Walter G. Barr, Barbara White, Arthur Weinstein, Daniel E. Furst, Michael H. Weisman, Steven R. Weiner |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Immunology Scleroderma Renal Crisis Physical examination Disability Evaluation Rheumatology Surveys and Questionnaires Internal medicine Bayesian multivariate linear regression medicine Health Status Indicators Humans Immunology and Allergy Pharmacology (medical) skin and connective tissue diseases Scleroderma Systemic Dose-Response Relationship Drug medicine.diagnostic_test business.industry Penicillamine Odds ratio medicine.disease Connective tissue disease Confidence interval Logistic Models Treatment Outcome Erythrocyte sedimentation rate Cohort Physical therapy business |
| Zdroj: | Arthritis & Rheumatism. 44:653-661 |
| ISSN: | 1529-0131 0004-3591 |
| Popis: | Objective To explore the clinical implications of a score of ≥1.0 on the Disability Index of the Health Assessment Questionnaire (HAQ DI) at the first patient visit, and to examine the implications of improvement in HAQ DI score over 2 years in a cohort of systemic sclerosis (SSc) patients with diffuse cutaneous scleroderma. Methods SSc skin and visceral involvement was assessed in 134 SSc patients with diffuse scleroderma (mean ± SD disease duration of 10 ± 4 months) when they entered a multicenter drug trial and again 2 years later. Mortality and the occurrence of scleroderma renal crisis were assessed for a mean ± SD of 4.0 ± 1.1 years. Logistic and linear regression analyses were used to examine the relationship of the baseline HAQ DI score to morbidity, mortality, and visceral involvement, as well as the relationship of changes in the HAQ DI score to changes in physical examination, laboratory, and functional variables over 2 years. Results A baseline HAQ DI score of ≥1.0 was predictive of mortality (odds ratio 3.22, 95% confidence interval 1.097–9.468) over 4 years. Multivariate linear regression demonstrated that a model which included the erythrocyte sedimentation rate at baseline (P = 0.005) and changes at 2 years in the swollen joint count (P = 0.002), total skin score (P = 0.005), and white blood cell count (P = 0.005) best explained the change in HAQ DI score over 2 years (R2 = 0.528). The HAQ DI score and total skin score at baseline were highly correlated (correlation coefficient 0.368), as were changes in the HAQ DI score and the total skin score over 2 years (correlation coefficient 0.492). Although the HAQ DI score was heavily influenced by hand dysfunction at baseline and at 2 years, improvement (reduction) in the HAQ DI score over 2 years was related to factors other than hand dysfunction. Conclusion A baseline HAQ DI score of ≥1.0 predicted mortality over 4 years. Improvement in the HAQ DI score in these patients with diffuse scleroderma was associated with improvement in skin thickening, hand function, oral aperture, lung function, signs of arthritis, serum creatinine level, and the investigator's global assessment of improvement. The HAQ DI is a self-administered questionnaire that SSc patients can complete easily and rapidly and that gives the practicing physician important information about prognosis, patient status, and changes in disease course over time. |
| Databáze: | OpenAIRE |
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