Social dysfunction is transdiagnostically associated with default mode network dysconnectivity in schizophrenia and Alzheimer’s disease

Autor: Nic J.A. van der Wee, Gerard R. Dawson, Ilja M.J. Saris, Amy C. Bilderbeck, Martien J H Kas, Lianne M. Reus, Celso Arrango, Maarten Mennes, Asad Malik, Pieter Jelle Visser, Brenda W. J. H. Penninx, José Luis Ayuso-Mateos, Hugh Marston, Sanne Koops, Moji Aghajani, Yolande A.L. Pijnenburg, A. Raslescu
Přispěvatelé: Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, APH - Mental Health, Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Neurology, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Complex Trait Genetics, APH - Digital Health, UAM. Departamento de Psiquiatría, Centro Colaborador de la Organización Mundial de la Salud para Docencia e Investigación en Servicios de Salud Mental, Kas lab
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: World Journal of Biological Psychiatry, 23(4), 264-277. Taylor and Francis Ltd.
World Journal of Biological Psychiatry. TAYLOR & FRANCIS LTD
World Journal of Biological Psychiatry
PRISM consortium 2022, ' Social dysfunction is transdiagnostically associated with default mode network dysconnectivity in schizophrenia and Alzheimer’s disease ', World Journal of Biological Psychiatry, vol. 23, no. 4, pp. 264-277 . https://doi.org/10.1080/15622975.2021.1966714
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
The World Journal of Biological Psychiatry, 23(4), 264-277. Taylor & Francis Ltd
ISSN: 1562-2975
Popis: Objectives: Social dysfunction is one of the most common signs of major neuropsychiatric disorders. The Default Mode Network (DMN) is crucially implicated in both psychopathology and social dysfunction, although the transdiagnostic properties of social dysfunction remains unknown. As part of the pan-European PRISM (Psychiatric Ratings using Intermediate Stratified Markers) project, we explored cross-disorder impact of social dysfunction on DMN connectivity. Methods: We studied DMN intrinsic functional connectivity in relation to social dysfunction by applying Independent Component Analysis and Dual Regression on resting-state fMRI data, among schizophrenia (SZ; N=48), Alzheimer disease (AD; N=47) patients and healthy controls (HC; N=55). Social dysfunction was operationalised via the Social Functioning Scale (SFS) and De Jong-Gierveld Loneliness Scale (LON). Results: Both SFS and LON were independently associated with diminished DMN connectional integrity within rostromedial prefrontal DMN subterritories (pcorrected range=0.02–0.04). The combined effect of these indicators (Mean.SFS + LON) on diminished DMN connectivity was even more pronounced (both spatially and statistically), independent of diagnostic status, and not confounded by key clinical or sociodemographic effects, comprising large sections of rostromedial and dorsomedial prefrontal cortex (pcorrected =0.01). Conclusions: These findings pinpoint DMN connectional alterations as putative transdiagnostic endophenotypes for social dysfunction and could aid personalised care initiatives grounded in social behaviour
The project leading to this application has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115916. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA. This publication reflects only the author’s views and neither the IMI 2JU nor EFPIA nor the European Commission are liable for any use that may be made of the information contained therein
Databáze: OpenAIRE
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