Serial optical coherence tomography assessment of malapposed struts after everolimus-eluting stent implantation. A subanalysis from the HEAL-EES study

Autor: Xavier Freixa, Yoshitaka Shiratori, Kohki Ishida, Victoria Martin-Yuste, Mónica Masotti, Salvatore Brugaletta, Giuseppe Giacchi, Luis Ortega-Paz, Manel Sabaté, Shuji Otsuki
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Everolimus eluting stent
Coronary Artery Disease
030204 cardiovascular system & hematology
Prosthesis Design
Group B
03 medical and health sciences
Percutaneous Coronary Intervention
0302 clinical medicine
Optical coherence tomography
Predictive Value of Tests
Neointima
medicine
Humans
Everolimus
030212 general & internal medicine
Aged
Randomized Controlled Trials as Topic
Retrospective Studies
medicine.diagnostic_test
business.industry
Coronary Thrombosis
Percutaneous coronary intervention
Stent
Cardiovascular Agents
Drug-Eluting Stents
General Medicine
Incomplete stent apposition
Middle Aged
Coronary Vessels
Treatment Outcome
Drug-eluting stent
Conventional PCI
Female
Radiology
Cardiology and Cardiovascular Medicine
business
Tomography
Optical Coherence
Zdroj: Cardiovascular Revascularization Medicine. 18:47-52
ISSN: 1553-8389
DOI: 10.1016/j.carrev.2016.08.010
Popis: Incomplete stent apposition (ISA) is related to stent thrombosis, which is a serious adverse event. We aim to assess the time-course of ISA after 2nd generation everolimus-eluting stent (EES) implantation.In HEAL-EES study, we enrolled 36 patients who underwent percutaneous coronary intervention (PCI) with EES. OCT imaging was performed at baseline and follow-up. Patients were randomized 1:1:1 into 3 groups according to the time in which follow-up was performed: group A (6-month), group B (9-month), and group C (12-month). In this subanalysis, patients who had ISA segments at baseline and/or follow-up OCT were analyzed.At baseline, among 41 lesions in 36 patients, 20 lesions in 18 patients had ISA segments and were analyzed. At baseline, there were 3.0% ISA struts in group A (n=8), 2.8% in group B (n=4), and 4.5% in group C (n=8). At follow-up, ISA struts were present in 0.09%, 0.16% and 0.64%; respectively in groups A, B, and C. At follow-up, there was a significant decrease in the frequency of ISA: group A 3.0% vs. 0.09% (p0.001), group B 2.8% vs. 0.16% (p0.001), and group C 4.5% vs. 0.64% (p0.001). In group A, there was one late acquired ISA at follow-up.In patients undergoing 2nd generation EES implantation, area of acute ISA assessed by OCT, was almost resolved at 6-month follow-up.
Databáze: OpenAIRE
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