Measles-Associated Encephalopathy in Children with Renal Transplants
| Autor: | E. Hughes, B. Cohen, A. Turner, F. Haworth, L. Jin, I. M. Kidd, Susan P. A. Rigden, Eithne MacMahon, D. Jeyaratnam, Manish D. Sinha |
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| Rok vydání: | 2006 |
| Předmět: |
Pediatrics
medicine.medical_specialty Adolescent Biopsy medicine.medical_treatment Encephalopathy Measles Measles virus Rubella vaccine medicine Humans Immunology and Allergy Pharmacology (medical) Child Kidney transplantation Transplantation biology business.industry Brain Infant Immunosuppression medicine.disease biology.organism_classification Kidney Transplantation Surgery Vaccination Treatment Outcome Subacute Sclerosing Panencephalitis business Measles-Mumps-Rubella Vaccine medicine.drug |
| Zdroj: | American Journal of Transplantation. 6:1459-1465 |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/j.1600-6143.2006.01330.x |
| Popis: | Two children, boys of 8 and 13 years, presented with measles-associated encephalopathy several years after kidney transplantation for congenital nephrotic syndrome. In the absence of prior clinical measles, the neurological symptoms initially eluded diagnosis, but retrospective analysis of stored samples facilitated the diagnosis of measles-associated encephalopathy without recourse to biopsy of deep cerebral lesions. Each had received a single dose of measles mumps and rubella vaccine before 12 months of age. Prior vaccination, reduction of immunosuppression and treatment with intravenous immunoglobulin and ribavirin may have contributed to their survival. Persistent measles virus RNA shedding, present in one child, was not controlled by treatment with i.v. ribavirin. Two years later, both patients continue to have functioning allografts with only minimal immunosuppression. These cases illustrate the difficulty in diagnosing measles-associated encephalopathy in the immunocompromised host, even in the era of molecular diagnostics, and highlight the renewed threat of neurological disease in communities with incomplete herd immunity. |
| Databáze: | OpenAIRE |
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