Neuroprotection against CCl4induced brain damage with crocin in Wistar rats

Autor:	Semir Gul, Harika Gozukara Bag, Yusuf Turkoz, Mehmet Gul, Gül Büşra Kaya, Mehmet Erman Erdemli, Zeynep Aksungur, Eyup Altinoz
Přispěvatelé:	0-Belirlenecek, Altinoz, E., Department of Medical Biochemistry, Faculty of Medicine, Karabuk University, Karabuk, Turkey -- Erdemli, M.E., Department of Medical Biochemistry, Faculty of Medicine, Nigde Omer Halisdemir University, Nigde, Turkey -- Gul, M., Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkey -- Aksungur, Z., Department of Medical Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey -- Gul, S., Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkey -- Bag, H.G., Department of Biostatistics, Faculty of Medicine, Inonu University, Malatya, Turkey -- Kaya, G.B., Department of Physiology, Faculty of Medicine, Inonu University, Malatya, Turkey -- Turkoz, Y., Department of Medical Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey
Rok vydání:	2018
Předmět:	malondialdehyde 0301 basic medicine Histology Brain damage Pharmacology medicine.disease_cause digestive system Neuroprotection Crocin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine parasitic diseases medicine oxidative stress glutathione biology Chemistry ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS catalase General Medicine Glutathione Malondialdehyde digestive system diseases crocin ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS Medical Laboratory Technology ComputingMethodologies_PATTERNRECOGNITION 030104 developmental biology Catalase biology.protein Carbon tetrachloride carbon tetrachloride InformationSystems_MISCELLANEOUS medicine.symptom 030217 neurology & neurosurgery Oxidative stress
Zdroj:	Biotechnic & Histochemistry. 93:623-631
ISSN:	1473-7760 1052-0295 3027-3072
DOI:	10.1080/10520295.2018.1519725
Popis:	PubMed ID: 30273072 Owing to its lipophilic property, carbon tetrachloride (CCl 4 ) is rapidly absorbed by both the liver and brain. We investigated the protective effects of crocin against brain damage caused by CCl 4 . Fifty rats were divided into five groups of ten: control, corn oil, crocin, CCl 4 and CCl 4 + crocin. CCl 4 administration decreased glutathione (GSH) and total antioxidant status (TAS) levels, and catalase (CAT) activity, while significant increases were observed in malondialdehyde (MDA) and total oxidant status (TOS) levels and superoxide dismutase (SOD) activity. The cerebral cortex nuclear lamina developed a spongy appearance, neuronal degeneration was observed in the hippocampus, and heterochromatic and pyknotic neurons with increased cytoplasmic eosinophilia were observed in the hippocampus after CCl 4 treatment. Because crocin exhibits strong antioxidant properties, crocin treatment increased GSH and TAS levels and CAT activities, and decreased MDA and TOS levels and SOD activity; significant improvements also were observed in histologic architecture. We found that crocin administration nearly eliminated CCl 4 induced brain damage by preventing oxidative stress. © 2018, © 2018 The Biological Stain Commission.
Databáze:	OpenAIRE
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