Prognostic value of textural indices extracted from pretherapeutic 18‐F FDG‐PET/CT in head and neck squamous cell carcinoma
| Autor: | David Bourhis, Olivier Delcroix, Catherine Guezennec, Fanny Orlhac, Philippe Robin, Ronan Abgral, Pierre-Yves Salaun, Yves Gobel, Ulrike Schick, Jean Rousset |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Multivariate analysis Standardized uptake value 030218 nuclear medicine & medical imaging Cohort Studies 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Predictive Value of Tests Positron Emission Tomography Computed Tomography medicine Humans Aged Neoplasm Staging PET-CT Univariate analysis Squamous Cell Carcinoma of Head and Neck business.industry Univariate Metabolic tumor volume Middle Aged Prognosis medicine.disease Head and neck squamous-cell carcinoma Tumor Burden Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Female Fdg pet ct Radiopharmaceuticals Nuclear medicine business |
| Zdroj: | Head & Neck. |
| ISSN: | 1097-0347 1043-3074 |
| Popis: | Background This study aimed at assessing the prognostic value of textural indices extracted from 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)/CT in a large cohort of patients with head and neck squamous cell carcinomas (HNSCC) of any anatomic subsite and staging. Methods Consecutive patients with HNSCC referred for a pretreatment FDG-PET/CT were retrospectively included and followed up for a minimum of 2 years. Standardized uptake value, metabolic tumor volume (MTV), and textural indices were calculated using LIFEx software. Prognostic significance of parameters was assessed in univariate and multivariate analysis. Results Textural indices were extracted in 284 patients (mean age = 63.7±9.6 years). In univariate analysis, MTV and 4 textural indices-Correlation, Entropy, Energy, and Coarseness-were significantly correlated with overall survival (OS). In multivariate analysis, MTV (P = .008) and Correlation (P = .028) remained independently correlated to OS. Conclusion This study showed that MTV and 1 textural index extracted from pretherapeutic FDG-PET/CT (Correlation) were independent prognostic factors of OS in patients with HNSCC. |
| Databáze: | OpenAIRE |
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