Synthesis and Anti-proliferative Activity of 4H-Chromone Based Phenylhydrazones, Pyrazolecarboxylates and Pyrazolylmethanones
| Autor: | V. Kalivendi Shasi, Rajkumar Kommera, Nageswara Rao Rayala, China Raju Bhimapaka, Ramalinga Murthy Thampunuri, Dayakar Cherupally |
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| Rok vydání: | 2018 |
| Předmět: |
Stereochemistry
Cell Survival Substituent Hydrazone Antineoplastic Agents 02 engineering and technology 010402 general chemistry Ring (chemistry) 01 natural sciences HeLa chemistry.chemical_compound Structure-Activity Relationship DU145 Cell Line Tumor Moiety Humans Cell Proliferation chemistry.chemical_classification biology Cycloaddition Reaction Molecular Structure Hydrazones 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences chemistry Chromones Chromone Pyrazoles Drug Screening Assays Antitumor 0210 nano-technology Oxidation-Reduction Methyl group |
| Zdroj: | Acta chimica Slovenica. 65(1) |
| ISSN: | 1318-0207 |
| Popis: | Series of 4 H -chromone-based hydrazones 3a – z , pyrazolecarboxylates 5a – x and pyrazolylmethanones 6a – u were prepared and screened for their anti-proliferative activity on A549, HeLa, DU145 and MDAMB 231 cell lines. The hydrazone compound 3s with a chloro substituent on the chromanone moiety and a methoxy group on the phenyl ring displayed promising activity on A549, HeLa and DU145 cell lines. The compound 5p with a bromo substituent on the chromanone moiety and a methyl group on the phenyl ring displayed potent activity on DU145. Furopyrazolecarboxylate 5w having a methyl substituent on the phenyl ring displayed potent activity on HeLa cell line. The pyrazolylmethanone 6e with a fluoro substituent on the phenyl ring and compound 6j having a methyl substituent on the chromanone moiety and a methoxy group on the phenyl ring have shown promising anti-proliferative activity on HeLa cell line. |
| Databáze: | OpenAIRE |
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