Intraoperative methadone for postoperative pain after laparoscopic hysterectomy: Protocol for a randomised, double-blind trial

Autor:	Lone D Brix, Kristian D. Friesgaard, Lone Nikolajsen, Omar Rian, Christina B Kristensen
Rok vydání:	2019
Předmět:	Abdominal pain Critical Care medicine.medical_treatment Hysterectomy MORPHINE Pacu law.invention ANALGESIA 03 medical and health sciences 0302 clinical medicine Patient satisfaction Randomized controlled trial Double-Blind Method 030202 anesthesiology law medicine Humans Aged Pain Measurement Aged 80 and over Pain Postoperative Intraoperative Care biology business.industry 030208 emergency & critical care medicine Visceral pain General Medicine Middle Aged biology.organism_classification PREVENTION Analgesics Opioid Anesthesiology and Pain Medicine Cough Patient Satisfaction Anesthesia Postoperative Nausea and Vomiting Female Laparoscopy medicine.symptom business Postoperative nausea and vomiting Methadone medicine.drug
Zdroj:	Friesgaard, K D, Brix, L D, Kristensen, C B, Rian, O & Nikolajsen, L 2019, ' Intraoperative methadone for postoperative pain after laparoscopic hysterectomy : Protocol for a randomised, double-blind trial ', Acta Anaesthesiologica Scandinavica, vol. 63, no. 9, pp. 1257-1261 . https://doi.org/10.1111/aas.13433
ISSN:	1399-6576
DOI:	10.1111/aas.13433
Popis:	Background Hysterectomy is often carried out as same-day surgery. Treatment of postoperative pain is, therefore, of utmost importance to ensure timely discharge from hospital. Methadone has several desirable pharmacological features, including a long elimination half-life. Theoretically, a single intraoperative dose could provide long-lasting pain relief. Methods This is a single-centre, investigator-initiated, randomised, double-blind study. Two-hundred and fifty women, scheduled to undergo hysterectomy at Horsens Region Hospital, Denmark, are randomized to receive methadone (0.2 mg/kg) or morphine (0.2 mg/kg) intraoperatively, 60 minutes before extubation. Primary outcomes are opioid consumption at 6 and 24 hours. Secondary outcomes include pain intensity at rest and during coughing at 1, 3, 6, 24 and 48 hours; patient satisfaction at 3 and 24 hours, postoperative nausea and vomiting at 6, 24 and 72 hours, adverse events in the postanaesthesia care unit (PACU) and time until readiness for discharge. Another outcome is persistent abdominal pain after 4 months. Conclusions The study outlined in this protocol will provide important information about the use of methadone in same-day hysterectomy patients. The results will presumably be applicable to other types of surgery involving visceral pain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd03e332a3430ed0ef20d4e8bd4d0e6 https://pubmed.ncbi.nlm.nih.gov/31276190 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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