Left atrial Frank-Starling law assessed by real-time, three-dimensional echocardiographic left atrial volume changes
| Autor: | Attila Nemes, Folkert J. ten Cate, Osama Ibrahim Ibrahim Soliman, Marcel L. Geleijnse, Ashraf M. Anwar |
|---|---|
| Přispěvatelé: | Cardiothoracic Surgery, Cardiology |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Left atrium Pump function Echocardiography Three-Dimensional Contractility Left atrial Internal medicine Medicine Humans Heart Atria Observer Variation Frank–Starling law of the heart business.industry Models Cardiovascular Heart Stroke Volume Stroke volume Middle Aged Atrial Function Myocardial Contraction Surgery Preload medicine.anatomical_structure Circulatory system Cardiology Female Cardiology and Cardiovascular Medicine business Cardiac Imaging and Non-Invasive Testing |
| Zdroj: | Heart, 93(11), 1393-1397. BMJ Publishing Group |
| ISSN: | 1355-6037 |
| DOI: | 10.1136/hrt.2006.099366 |
| Popis: | The Frank-Starling law describes the relation between left ventricular volume and function. However, only a few studies have described the relation between left atrial volume (LAV) and function.To describe an LA Frank-Starling law by studying changes in LAV measured by real-time, three-dimensional echocardiography (RT3DE).LAV was calculated by RT3DE in 70 patients at end-systole (LAV(max)), end-diastole (LAV(min)) and pre-atrial contraction (LAV(pre-A)). According to LAV(max), patients were classified into three groups: LAV(max)50 ml (group I), LAV(max) 50-70 ml (group II) and LAV(max)70 ml (group III). Calculated indices of LA pump function were active atrial stroke volume (SV), defined as LAV(pre-A) - LAV(min), and active atrial emptying fraction (EF), defined as active atrial SV/LAV(pre-A) x100%Active atrial SV was significantly higher in group II than in group I (mean (SD) 19.0 (9.2) vs 8.2 (4.9) ml, p0.0001), in group III it was non-significantly lower than in group II (16.7 (12.5) vs 19.0 (9.2) ml). Active atrial SV correlated well with LAV(pre-A) (r = 0.56, p0.001), but decreased with larger LAV(pre-A). Active atrial EF tended to be higher in group II than in group I (43.1 (18.2) vs 33.2 (17.5), p0.10), in group III it was significantly lower than in group II (26.2 (18.5) vs 43.1 (18.2), p0.01).A Frank-Starling mechanism in the left atrium could be described by RT3DE, shown by an increase in LA contractility in response to an increase in LA preload up to a point, beyond which LA contractility decreased. |
| Databáze: | OpenAIRE |
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