Functional Independence After Stroke Thrombectomy Using Thrombolysis In Cerebral Infarction Grade 2c: A New Aim of Successful Revascularization
| Autor: | Timothy R Miller, Dheeraj Gandhi, Gaurav Jindal, Varun Naragum, Rong Chen, Matthew J Kole, John Cole, Ravishankar Shivashankar, Jose G. Merino, Nathan Kohler |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Demographics medicine.medical_treatment 030204 cardiovascular system & hematology Revascularization 03 medical and health sciences 0302 clinical medicine Fibrinolytic Agents Internal medicine Activities of Daily Living medicine Humans Prospective Studies Stroke Retrospective Studies Thrombectomy Retrospective review Cerebral Revascularization business.industry Cerebral infarction Significant difference Infarction Middle Cerebral Artery Thrombolysis Recovery of Function Length of Stay Middle Aged medicine.disease Treatment Outcome Tissue Plasminogen Activator Cardiology Functional independence Surgery Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | World neurosurgery. 119 |
| ISSN: | 1878-8769 |
| Popis: | Background Within the Thrombolysis In Cerebral Infarction (TICI) classification, TICI 2b has been historically considered successful recanalization. However, TICI 2b may result in worse functional outcomes compared with TICI 3 or a proposed TICI 2c revascularization grade. The aim of this study was to evaluate differences in functional independence at 90 days between TICI 2b, 2c, and 3 grades. Methods A retrospective review of 185 consecutive patients with anterior cerebral circulation occlusions was performed; 33 patients who were treated >8 hours after onset were excluded. Patient angiograms were graded by 2 experienced neurointerventional physicians. Baseline demographics and functional independence at 90 days were compared. Results Of 152 patients included in the study, 113 patients achieved TICI grade 2b (n = 37), 2c (n = 34), or 3 (n = 42). A significant difference in functional independence at 90 days was observed between TICI 2b and 2c/3 (P = 0.0008), between 2b and 2c (P = 0.0005), and between 2b and 3 (P = 0.01). There was no significant difference in functional independence between 2c and 3 (P = 0.24). Conclusions TICI 2c revascularization is associated with significantly improved outcomes compared with TICI 2b revascularization and similar outcomes compared with TICI 3 revascularization. Using a TICI grading system that includes an additional TICI 2c grade or expands the current definition of TICI 3 allows for refined prediction of functional independence. Achieving TICI 2c/3 reperfusion should be considered during stroke thrombectomy. |
| Databáze: | OpenAIRE |
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