Preoperative hormonal pattern in patients undergoing radical prostatectomy due to prostate cancer
| Autor: | Albert Carrion, Eduardo García-Cruz, Juan Alcover, Asier Leibar‐Tamayo, Andrea Sallent, Roberto Castañeda-Argáiz, Javier Romero-Otero, Antonio Alcaraz |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Biochemical recurrence medicine.medical_specialty Neoplasms Hormone-Dependent medicine.medical_treatment Urology Kaplan-Meier Estimate Adenocarcinoma Prostate cancer Sex hormone-binding globulin Sex Hormone-Binding Globulin Preoperative Care Humans Medicine Testosterone Prospective Studies Stage (cooking) Pathological Aged Prostatectomy biology business.industry Prostatic Neoplasms Testosterone (patch) General Medicine Middle Aged Prostate-Specific Antigen medicine.disease Tumor Burden biology.protein Neoplasm Grading business Follow-Up Studies Hormone |
| Zdroj: | Actas Urológicas Españolas (English Edition). 37:280-285 |
| ISSN: | 2173-5786 |
| Popis: | Objective There is controversial evidence regarding preoperative testosterone levels related to poor prognosis factors after radical prostatectomy. The aim of this manuscript is to determine the relationship between preoperative testosterone levels and final pathologic report together to biochemical recurrence after radical prostatectomy (RP). Materials and methods We prospectively analyzed 143 patients submitted to RP from February 2008 to June 2010 in our center. Pre-treatment testosterone (T) and sex hormone-binding globulin (SHBG) levels were determined as part of our clinical protocol. Free calculated (fT) and bioavailable (bioT) testosterone were calculated using Vermeulen's formula. Low testosterone levels were defined as 346 ng/dL or less. A comparative analysis with variables pTNM, positive margins, tumor burden, Gleason score, multifocality and biochemical recurrence (using both PSA > 0.4 ng/dL and PSA > 0.2 ng/dL as cut-off values) was performed, according to preoperative levels of T. Results Variables Gleason score, rate and number of positive margins, tumor burden, tumor multifocality, time to biochemical recurrence and pathological stage were not related to preoperative hormonal levels. Preoperative T 0.4 ng/dL log-rank, p = 0.512), although a trend was observed when PSA > 0.2 ng/dL (log-rank, p = 0.097). Conclusion Preoperative testosterone levels were not related to final pathological report or to biochemical recurrence. |
| Databáze: | OpenAIRE |
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