Antipyretic activity of Caesalpinia digyna (Rottl.) leaves extract along with phytoconstituent’s binding affinity to COX-1, COX-2, and mPGES-1 receptors: In vivo and in silico approaches
| Autor: | Nazim Uddin Emon, Safaet Alam, Sajib Rudra, Md. Ezazul Hoque Rana, Ibrahim Khalil Al Haidar, Mohammed Farhad, Amlan Ganguly |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0301 basic medicine QH301-705.5 In silico Pharmacology 01 natural sciences 03 medical and health sciences Caesalpinia digyna In vivo medicine Antipyretic Biology (General) Receptor ADME biology Chemistry COX mPGES-1 biology.organism_classification 030104 developmental biology Docking (molecular) Ethnopharmacology General Agricultural and Biological Sciences Pyrexia 010606 plant biology & botany medicine.drug Discovery Studio |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 28, Iss 9, Pp 5302-5309 (2021) |
| Popis: | Caesalpinia digyna (Rottl.) (Family: Fabaceae) is well known for its numerous medicinal values against several human disorders including fever, senile pruritis, diarrhea, tuberculosis, tonic disorder, diabetes, etc. The current study is intended to investigate the in vivo antipyretic activity of the methanol extract of C. digyna leaves (MECD) and its carbon-tetrachloride (CTCD) and butanol fraction (BTCD). Besides, in silico molecular docking and ADME/T profiling of the selective identified bioactive compounds of C. digyna has been also studied to validate the experimental outcomes and establish a better insight into the possible receptor-ligand interaction affinity. In vivo antipyretic activity of MECD, CTCD and BTCD were evaluated by employing yeast induced pyrexia technique in mice model and in silico analysis of the identified compounds of C. digyna has been implemented using PyRx autodock vina, Discovery Studio 2020, UCSF Chimera software and ADME/T online tools. MECD and BTCD unveiled significant antipyretic activity in dose dependent manner whereas, CTCD failed to exhibit significant antipyretic activity. Comparing to other test sample, MECD (400 mg/kg; b.w) (p |
| Databáze: | OpenAIRE |
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