Ruthenium-Catalyzed Heck-Type Alkenylation of Alkyl Bromides
| Autor: | Pedro J. Pérez, José María Muñoz-Molina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Base (chemistry) 010405 organic chemistry Chemistry Alkenylation Organic Chemistry Alkyl radicals chemistry.chemical_element Homogeneous catalysis 010402 general chemistry Single electron transfer 01 natural sciences Medicinal chemistry Coupling reaction 0104 chemical sciences Catalysis Ruthenium Metal visual_art visual_art.visual_art_medium Cross-coupling Ruthenium catalysis Alkyl |
| Zdroj: | Arias Montano. Repositorio Institucional de la Universidad de Huelva instname |
| Popis: | The complex [Cp*RuCl(PPh3)2] displays a high catalytic activity for the Heck-type alkenylation of alkyl bromides, in the first example using this metal under thermal conditions. The coupling reaction proceeds efficiently with a variety of functionalized tertiary, secondary, and primary alkyl bromides. The presence of Hünig’s base has been revealed crucial for this transformation. Preliminary mechanistic studies support the participation of alkyl radicals in the reaction. We thank MINECO for a grant (CTQ2017-82893-C2-1-R). We also thank Francisco Molina for X-ray structure determination |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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