Divergent effects of isolation rearing on prepulse inhibition, activity, anxiety and hippocampal-dependent memory in Roman high- and low-avoidance rats: A putative model of schizophrenia-relevant features
| Autor: | Ana Sánchez-González, Cristóbal Río-Álamos, Cristina Gerbolés, Maria Antonietta Piludu, Alberto Fernández-Teruel, Ignasi Oliveras, Adolf Tobeña |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Anxiety Hippocampal formation Hippocampus Spatial memory Developmental psychology 03 medical and health sciences Behavioral Neuroscience Cognition 0302 clinical medicine Prepulse inhibition activity Avoidance Learning medicine Animals Social isolation Prepulse inhibition Behavior Animal Prepulse Inhibition medicine.disease Anxiety Disorders Isolation rearing Rats 030227 psychiatry Memory Short-Term Schizophrenia medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Behavioural Brain Research. 314:6-15 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2016.07.047 |
| Popis: | Social isolation of rats induces a constellation of behavioral alterations known as "isolation syndrome" that are consistent with some of the positive and cognitive symptoms observed in schizophrenic patients. In the present study we have assessed whether isolation rearing of inbred Roman high-avoidance (RHA-I) and Roman low-avoidance (RLA-I) strains can lead to the appearance of some of the key features of the "isolation syndrome", such as prepulse inhibition (PPI) deficits, increased anxious behavior, hyperactivity and memory/learning impairments. Compared to RLA-I rats, the results show that isolation rearing (IR) in RHA-I rats has a more profound impact, as they exhibit isolation-induced PPI deficits, increased anxiety, hyperactivity and long-term reference memory deficits, while isolated RLA-I rats only exhibit deficits in a spatial working memory task. These results give further support to the validity of RHA-I rats as a genetically-based model of schizophrenia relevant-symptoms. |
| Databáze: | OpenAIRE |
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