Evidence for the ability of central 5-HT1A receptors to modulate the vagal bradycardia induced by stimulating the upper airways of anesthetized rabbits with smoke
| Autor: | J. G. P. Pires, Henrique A. Futuro-Neto, Michael P. Gilbey, Andrew G. Ramage |
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| Rok vydání: | 1993 |
| Předmět: |
Bradycardia
medicine.medical_specialty Apnea Blood Pressure Kidney Buspirone Heart Rate Internal medicine Heart rate medicine Animals Anesthesia Receptor Molecular Biology Injections Intraventricular Motor Neurons 8-Hydroxy-2-(di-n-propylamino)tetralin business.industry General Neuroscience Smoking Vagus Nerve Atenolol Stimulation Chemical Vagus nerve Autonomic nervous system Endocrinology Receptors Serotonin Reflex Rabbits Neurology (clinical) medicine.symptom business Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 629:349-354 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(93)91345-s |
| Popis: | Cigarette smoke passed through the nasal cavity of atenolol pre-treated anesthetized spontaneously breathing rabbits caused a bradycardia which was significantly modified by intracisternal application of the 5-HT 1A receptor ligands 8-OH-DPAT (50 μg·kg −1 ) and buspirone (200 μg·kg −1 ). 8-OH-DPAT attenuated while buspirone potentiated the bradycardia. These results support the view that 5-HT 1A receptors play an important role in modulating the excitability of cardiac vagal motoneurones. |
| Databáze: | OpenAIRE |
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